jhonek

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1. Personal Information

Name
John F. Honek
My web page
http://www.science.uwaterloo.ca/%7ejhonek/
Organization(s)
Canadian Chemical Society, American Chemical Society

2. Community Expertise

Schistosomiasis research
Malaria research
Tuberculosis research community
The Synaptic Leap community
Skills
Enzimology

3. Publications

Publications

J. F. Honek, Chapter 24, "Fluorinated Methionines as Probes in Biological Chemistry" in "Current Fluoroorganic Chemistry. New Synthetic Directions, Technologies, Materials and Biological Applications" ACS Symposium Series; Soloshonok, V. A.; Mikami, K.; Yamazaki, T.; Welch, J. T., and Honek, J. Eds., Oxford University Press, in press (2006).
N. Sukdeo, E. Daub and J. F. Honek, 2006, Biochemistry of the Nickel-Dependent Glyoxalase I Enzymes in Metal Ions in Life Sciences, Volume 2 (Wiley), in press.
C. E. Hand, F.-I. Auzanneau and J. F. Honek, 2006, Conformational Analyses of Mycothiol, a Critical Intracellular Glycothiol in Mycobacteria. Carbohydrate Research, 341, 1164-1173.
P. Walasek and J. F. Honek, 2005, Nonnatural Amino Acid Incorporation into the Methionine 214 Position of the Metzincin Pseudomonas aeruginosa Alkaline Protease. BMC Biochemistry, 6: 21. (Open Access)
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M. D. Vaughan, P. B. Sampson. E. Daub and J. F. Honek, 2005, Investigation of Bioisosteric Effects on the Interaction of Substrates/Inhibitors with the Methionyl-tRNA Synthetase from Escherichia coli. Medicinal Chemistry, 1, 227-237.
C. E. Hand and J. F. Honek, 2005, Biological Chemistry of Naturally Occurring Intracellular Thiols of Microbial and Marine Origin. Journal of Natural Products, 68, 293-308.
P. C. Hang and J. F. Honek, 2005, Electronic Structure Calculations on the Thiazole-Containing Antibiotic Thiostrepton: Molecular Mechanics, Semi-Empirical and Ab initio Analyses. Bioorganic and Medicinal Chemistry Letters, 15, 1471-1474.
C. E. Hand, N. J. Taylor and J. F. Honek, 2005, Ab Initio Studies of the Properties of Intracellular Thiols Ergothioneine and Ovothiol. Bioorganic and Medicinal Chemistry Letters, 15, 1357-1360.
N. Sukdeo, S. L. Clugston, E. Daub and J. F. Honek, 2004, Distinct Classes of Glyoxalase I. Metal Specificity of the Yersinia pestis, Pseudomonas aeruginosa and Neisseria meningitidis Enzymes. Biochemical Journal, 384, 111-117.
S. L. Clugston, R. Yajima and J. F. Honek, 2004, Investigation of Metal Binding and Activation of E. coli Glyoxalase I: Kinetic, Thermodynamic and Mutagenesis Studies. Biochemical Journal, 377, 309-316.
S. L. Jacques, A. Mizra, L. Ejim, K. Koteva, D. W. Hughes, K. Green, R. Kinach, J. F. Honek, H. K. Lai, A. M. Berghuis and G. D. Wright, 2003 , Enzyme Assisted Suicide: Inhibitor Generation in the Active Site of Homoserine Dehydrogenase Accounts for the Antifungal Activity of 5-Hydroxy-4-Oxonorvaline. Chemistry and Biology, 10, 989-995.
B. Salopek-Sondi, M. D. Vaughan, M. C. Skeels, J. F. Honek and L. A. Luck, 2003, 19F NMR Studies of the Leucine-Isoleucine-Valine Binding Protein: Evidence That a Closed Conformation Exists in Solution. Journal of Biomolecular Structure and Dynamics, 21(2) 235-246..
T. Crepin, E. Schmitt, Y. Mechulam, P. B. Sampson, M. D. Vaughan, J. F. Honek and S. Blanquet, 2003, Use of Analogues of Methionine and Methionine Adenylate to Sample Conformational Changes During Catalysis in Escherichia coli Methionyl-tRNA Synthetase. Jour. Mol. Biol., 332, 59-72.
J. A. Steere and J. F. Honek, 2003, Synthesis and Biological Activity of Novel S-Adenosyl-L-Homocysteine Hydrolase Inhibitors. Bioorg. Med. Chem., 11, 3229-3236.
M. D. Vaughan, P. B. Sampson and J. F. Honek, 2002 , Methionine In and Out of Proteins: Targets for Drug Design. Current Medicinal Chemistry , 9, 385-409.
J. A. Steere, P. B. Sampson and J. F. Honek, 2002, Synthesis of an alpha-Aminophosphonate Nucleoside as an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase. Bioorg. Med. Chem. Lett., 12, 457-460.
H. S. Duewel, E. Daub, V. Robinson and J. F. Honek, 2001 , Elucidation of Solvent Exposure, Side-Chain Reactivity and Steric Demands of the Trifluoromethionine Residue in a Recombinant Protein. Biochemistry , 40, 13167-13176.
A. K.-W. Leung, H. S. Duewel, J. F. Honek and A. M. Berghuis, 2001 , Crystal Structure of the Lytic Transglycosylase from Bacteriophage Lambda in Complex with Hexa-N-Acetylchitohexaose. Biochemistry , 40, 5665-5673.
G. Davidson, S. L. Clugston, J. F. Honek, and M. J. Maroney, 2001 , An XAS Investigation of Product and Inhibitor Complexes of Ni-containing GlxI from E. coli: Mechanistic Implications. Biochemistry , 40, 4569-4582.
S. L. Jacques, C. Nieman, D. Bareich, G. Broadhead, R. Kinach, J. F. Honek and G. D. Wright, 2001, Characterization of Yeast Homoserine Dehydrogenase, an Antifungal Target: The Invariant Histidine 309 is Important for Enzyme Integrity. Biochim. Biophys. Acta, 1544, 28-41.
E. Stokvis, S. L. Clugston, J. F. Honek, and A. J. R. Heck, 2000 , Characterization of Glyoxalase I (E. coli)-Inhibitor Interactions by Electrospray Time-of-Flight Mass Spectrometry and Enzyme Kinetics. Jour. Prot. Chem., 19, 389-397.
M. M. He, S. L. Clugston, J. F. Honek, and B. W. Matthews, 2000 , Determination of the Structure of Escherichia coli Glyoxalase I Suggests a Structural Basis for Differential Metal Activation. Biochemistry , 39, 8719-8727.
G. Davidson, S. L. Clugston, J. F. Honek, and M. J. Maroney, 2000 , XAS Investigation of the Nickel Active Site Structure in Escherichia coli Glyoxalase I. Inorg. Chem. (ACS), 39 , 2962-2963..
W. T. Lowther, N. Brot, H. Weissbach, J. F. Honek, and B. W. Matthews, 2000, Thiol-Disulfide Exchange is Involved in the Catalytic Mechanism of Peptide Methionine Sulfoxide Reductase. Proc. Natl. Acad. Sci (USA), 97, 6463-6468.
S. L. Clugston and J. F. Honek, 2000, Identification of Sequences Encoding the Detoxification Metalloisomerase Glyoxalase I in Microbial Genomes from Several Pathogenic Organisms. Journal of Molecular Evolution , 50, 491-495.
M. D. Vaughan, P. Cleve, V. Robinson, H. S. Duewel, and J. F. Honek, 1999, Difluoromethionine as a Novel 19F NMR Structural Probe for Internal Amino Acid Packing in Proteins. Jour. Amer. Chem. Soc., 121, 8475-8478.
W. T. Lowther, Y. Zhang, P. B. Sampson, J. F. Honek, and B. W. Matthews, 1999, Insights into the Mechanism of Escherichia coli Methionine Aminopeptidase from the Structural Analysis of Reaction Products and Phosphorus-Based Transition-State Analogues. Biochemistry, 38, 14810-14819.
P. B. Sampson and J. F. Honek, 1999, Oxidative Deprotection of Diphenylmethylamines. Organic Letters (ACS), 1, 1395-1397.
S.L. Clugston, J.F.J. Barnard, R. Kinach, D. Miedema, R. Ruman, E. Daub and J.F. Honek, 1998, Overproduction and Characterization of a Dimeric Non-Zinc Glyoxalase I from Escherichia coli: Evidence for Optimal Activation by Nickel Ions. Biochemistry, 37, 8754-8763.
H.D. Ly, S.L. Clugston, P.B. Sampson, and J.F. Honek, 1998, Syntheses and Kinetic Evaluation of Hydroxamate- Based Peptide Inhibitors of Glyoxalase I. Bioorganic and Medicinal Chemistry Letters, 8, 705-710.
S.L. Clugston, E. Daub, and J.F. Honek, 1998, Identification of Glyoxalase I Sequences in Brassica oleracea and Sporobolus stapfianus: Evidence for Gene Duplication Events, Journal of Molecular Evolution, 47, 230-234.
H.S. Duewel and J.F. Honek 1998, CNBr/Formic Acid Reactions of Methionine- and Trifluoromethionine- Containing Lambda Lysozyme: Probing Chemical and Positional Reactivity and Formylation Side Reactions by Mass Spectrometry, Journal of Protein Chemistry 17, 337-350.
M.E. Houston Jr., L. Harvath, and J.F. Honek 1997, Syntheses of and Chemotactic Responses Elicited by fMet-Leu-Phe Analogs Containing Difluoro-and Trifluoromethionine. Bioorganic and Medicinal Chemistry Letters, 7, 3007-3012.
H. Duewel, E. Daub, V. Robinson and J.F. Honek 1997 Incorporation of Trifluoromethionine into a Phage Lysozyme: Implications and a New Marker for Use in Protein 19F NMR. Biochemistry 36, 3404-3416.
S.L. Clugston, E. Daub, R. Kinach, D. Miedema, J.F.J. Barnard and J.F. Honek 1997. Isolation and Sequencing of a Gene Coding for Glyoxalase I Activity from Salmonella typhimurium and Comparison with Other Glyoxalase I Sequences. Gene 186,103-111.
P.C. M. Chan, R.J. Roon, J.F. Koerner, N.J. Taylor and J.F. Honek 1995 A 3-Amino-4-Hydroxy-3-Cyclobutene- 1,2-Dione Containing Glutamate Analogue Exhibiting High Affinity to Excitatory Amino Acid Receptors. Journal of Medicinal Chemistry 38, 4433-4438.
M. Diaz-Diaz, O.P. Ward, J. Honek and G. Lajoie 1995 Enzymes from Pseudomonassp. NCIB 11097 Participating in Biotransformation of Acetaldehyde and Glycine to Threonine Isomers. Canadian Journal of Microbiology 41, 438-443.
H. S. Duewel, E. Daub and J. F. Honek 1995 Investigations of the Interactions of Saccharides with the Lysozyme from Bacteriophage Lambda Biochimica et Biophysica Acta 1247,149-158.

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