Rajiv Ratan

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1. Personal Information

Rajiv Ratan
Burke-Cornell Medical Research Institute, Weil Medical College of Cornell
Connotea username
Rajiv R. Ratan
CiteULike username
Rajiv R. Ratan

2. Community Expertise

The Synaptic Leap community
Cellular biology

3. Publications


1.) Keith, C.H., Ratan, R., Maxfield, F.R., Bajer, A. and Shelanski, M.L. (1985) Local cytoplasmic gradients in living mitotic cells. Nature (London) 315:848-850.
2.)Ratan,R.R., Maxfield, F.R., and Shelanski, M.L. (1986) Transition from metaphase to anaphase is accompanied by local changes in cytosolic free calcium in mammalian Pt K2 kidney epithelial cells. Proc. Natl. Acad. Sci. (USA) 83:5136-5140.
3.)Ratan, R.R. and Shelanski, M.L. (1986) Calcium and the regulation of mitotic events. Trends in Biochem. Sci. 11:456-459.
4.)Ratan, R.R.,Murphy, T.H., and Baraban, J.M. (1994) Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem. 62:376-379.
5.)Ratan, R.R.,Murphy, T.H., and Baraban, J.M. (1994) Macromolecular synthesis inhibitors inhibit oxidative stress-induced apoptosis by shunting cysteine from protein synthesis to glutathione. J. Neurosci. 7:6341-6348.
6.)Ratan, R.R. and Baraban, J.M. (1994) Apoptotic death in an in vitro model of neuronal oxidative stress. Clinical and Experimental Pharmacology and Physiology 22(4):309-310.
7.)Lin, K-I, Lee, S-W., Narayanan, R., Baraban, J.M., Hardwick, J.M., and Ratan, R.R. (1995) Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic signaling pathway that requires the transcription factor, NF-kB. J. Cell Biol. 131(5):1149-1161.
8.)Ratan, R.R., Lee, P.J., and Baraban, J.M. (1996) Serum deprivation inhibits glutathione depletion-induced death in embryonic cortical neurons: evidence against oxidative stress as a final common mediator of apoptosis. Neurochem. International. 29(2):153-157.
9.)Togashi, H., Sasaki, M., Frohman, E., Taira, E, Ratan, R,Dawson, T.M., and Dawson, V. (1997) Neuronal (Type 1) Nitric Oxide Synthase Regulates NF-kB activity and Immunologic (Type II) Nitric Oxide Synthase Expression., Proc. Natl. Acad. Sci. 94:2676-2680.
10.)Lin, K-I, Baraban, J.M., and Ratan, R.R. (1998) Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration. Cell Death and Differentiation.5:577-583.
11.) Habib, A.A., Hognason, T., Ren, J., Stefansson, K., and Ratan, R.R. (1998) The EGF Receptor associates with and recruits phosphatidylinositol 3-kinase to the PDGF Beta-receptor. J. Biol. Chem. 273:6885-6891.
12.)Esch, F., Lin, K-I., Hills, A., Zaman, K., Baraban J.M., Chattergee, S., Rubin, L., Ash, D.E., and Ratan, R.R. (1998) Purification of a multipotent anti-death activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis. J. Neurosci. 18:4083-4095
13.) Lin, K.-I., DiDonato, J., Hoffmann, A., Hardwick, J.M., and Ratan, R.R. (1998) Suppression of steady-state, but not stimulus induced NF-kB activity prevents alphavirus-induced apoptosis. J. Cell Biol. 141(7):1479-1487.
14.) Zaman, K., OíDonovan, K., Lin, K.-I., Miller, M.P., Marquis, J., Baraban, J.M., Semenza, G.L., and Ratan, R.R. (1999) Protection from oxidative stress-induced apoptosis in cortical neurons by iron chelators is associated with increased expression of glycolytic enzymes and enhanced DNA binding of hypoxia inducible factor-1 and ATF-1/CREB. J. Neuroscience. 19(22):9821-9830.
15.) Chatterjee, S., Zaman, K., Ryu, H, Conforto, A., and Ratan, R.R. (2000) The sequence selective DNA binding drugs mithramycin and chromomycin potently inhibit apoptosis induced by oxidative stress and DNA damage Ann. Neurol. 2001;49:345-354.
16.) Koliatosis, V.E., and Ratan, R.R. eds. (1998) Cell Death and Diseases of the Nervous System. Human Press, Totowa, N.J.
17.) Ryu, H., Lee, J.H., Oloffson, B., Deodoglu, A., Escudero, M., Flemington, E., Azizkhan, J-C., Ferrante, R.J., and Ratan. R.R (2003) Histone deacetylase inhibitors prevent oxidative neuronal death independently of polyglutamine expansions via an Sp1 dependent pathway. Proc Natl. Acad. Sci. 100(7): 4281-4286..

Publications (continued)
18.) Hoon Ryu,1,4,8 Junghee Lee,1,4 Khalequz Zaman,1,4 James Kubilis,6 Robert J. Ferrante,6 Brian D. Ross,7 Rachael Neve,2,3,5 and Rajiv R. Ratan. Sp1 and Sp3 Are Oxidative Stress-Inducible, Anti-Death Transcription Factors in Cortical Neurons (2003) J. Neuroscience, 23(9):3597-3606.
19.) Lee, J.H., Ryu, H., Ferrante, R.J., Morris, S.M., and Rajiv R. Ratan. Translational control of inducible nitric oxide synthase can explain the arginine paradox. (2003) Proc. Natl. Acad. Sci. 100(8):4843-8.
20.) Blass JP, Ratan RR.. Silent" strokes and dementia. N Engl J Med. 2003 Mar 27;348(13):1277-8.
21.) Ferrante, R.J., Kubilis, J.K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, NW., Ratan, R.R., Luthi-Carter, R., Hersch, S.M. (2003) Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington’s disease mice. J. Neurosci. 23(28):9418-9427.
22.) Langley, B. and Ratan, R.R. (2004) Oxidative stress induced death in the nervous system: cell cycle dependent or independent? J. Neuroscience Research 14: 1-7.
23.) Lange, P., Langley, B., Lu, P. and Ratan R.R. (2004) Novel roles for arginase in survival, translational control and regeneration in the central nervous system. J. Nutrition
24.) Ratan, R.R., Siddiq, A., Aminova, L., Lange, P., Langley, B., Gensert, J., and Chavez, J. (2004) Translating ischemic preconditioning to the patient: prolyl hydroxylase inhibition and HIF-1 activation as novel targets for stroke therapy. Stroke Nov; 35 (11 Suppl1) 2687-9.
25.) Ferrante, R.J., Ryu, H., Kubilis, J.K., D’Mello, S., Sugars, K.L., Lee, J., Lu P., Smith, K., Browne, S., Beal, M.F., Kristal, B.S., Stavrovskaya, I., Hewett, S., Rubinsztein, D.C., Langley, B., and Ratan, R.R. (2004) Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington’s disease. J. Neuroscience. Nov 17; 24(41):10335-42
26.) Ryu, H. Lee, J., Simon, D.K., Aminova, L., Andreyev, A., Kushnareva, Y., Murphy, A., Lonze, B., Ginty, D.D., Ferrante, R.J. and Ratan R.R. (2004) Mitochondrial CREB Regulates Mitochondrial Gene Expression and Neuronal Survival. JBC2005 Dec 9;280(49):40398-401. Epub 2005 Oct 5
27.) Aminova, L., Chavez, J., Lee, J., Ryu, H., Kung, A., LaManna, J., and Ratan R.R. (2004) Prosurvival and prodeath effects of HIF-1 stabilization in a hippocampal cell line. J. Biol. Chem. Nov. 22 (epub ahead of print)
28.) Ratan, R. R. (2004) CREB family transcription factors: the holy grail of neurological therapeutics? Annals of Neurology 56 (5): 607-609.
28.)Siddiq, A., Ayoub, I.A., Chavez, J.C., Aminova, L. Shah, S., La Manna, J.C., Patten, S.M., Connor, J.R., Cherney, R.A., Volitakis, I., Bush, A., Langsetmo, I., Seeley, T., Gunzler, V., and Ratan R. R. (2005) HIF 4-prolyl hydroxylase inhibition: a target for neuroprotection in the central nervous system. J. Biol. Chem. 280(50). 41732-41743.
29.) Ryu, H., Lee, J., Impey, S., Ratan RR., and Ferrante RJ. (2005) Antioxidants modulate mitochondrial PKA and increase CREB binding to the D-loop DNA of mitochondrial genome in neurons. Proc. Natl. Acad. Sci. USA. Sept 27th; 102(39): 139, 15-20.
30.) Leila R. Aminova1; Ambreena Siddiq1, Juan Chavez2and Rajiv R. Ratan1*2 (2005) Prevention of the prodeath effect of HIF-1ï¡ï€ by antioxidants, prolyl hydroxylase inhibition or short interfering RNAs to the BH3 only prodeath Bcl-2 family member, BNIP3, submitted.
31.) Krasnikov BF, Kim SY, McConoughey, SJ, Ryu, H, Xu H, Stavrovska I. Lismaa SE, Mearns BM, Ratan RR, Blass, JP, Gibson, GE, Cooper, AJ. Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry. 2005 May 31: 44(21): 7830-43.
32.) Camelo, S. Iglesias, AH, Hwang D, Due B, Ryu H, Smith K, Gray SG, Imitola J, Duran G. Assaf B, Langley B, Khoury SJ, Stephanopoulus G, De Girolami U, Ratan RR, Ferrante RJ, Dangond F. (2005) Transcirptional therapy with the histone deacetylase trichostatin A ameliorates experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005 Jul: 164 (1-2): 10-21.
33.) Langley, B., Gensert, JM, Beal, MF, Ratan RR. Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr Drug Targets CNS Neurol Disord. 2005. Feb: 4(1): 41-50. Review.
34.) van Leyen, K. Siddiq, A, Ratan RR, Lo EH. Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity. J Neurochem. 2005 Feb;92(4):824-30.
35.) Gensert, J. and Ratan, R.R. (2006) The metabolic coupling of arginine metabolism to nitric oxide generation by astrocytes. Antioxiants and Redox Signaling. In press.


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