Saj

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1. Personal Information

Name
Mohammed 'Saj' Sajid
My web page
http://profiles.ucsf.edu/ProfileDetails.aspx?Person=4650710

2. Community Expertise

Malaria research
Schistosomiasis research
The Synaptic Leap community
Skills
Parasitology

3. Publications

Publications

1. Annoura T, Ploemen IH, van Schaijk BC, Sajid M, Vos MW, van Gemert GJ, Chevalley-Maurel S, Franke-Fayard BM, Hermsen CC, Gego A, Franetich JF, Mazier D, Hoffman SL, Janse CJ, Sauerwein RW, Khan SM. Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates. Vaccine. 2012 Mar 30; 30(16):2662-70.
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2. Lin JW, Annoura T, Sajid M, Chevalley-Maurel S, Ramesar J, Klop O, Franke-Fayard BM, Janse CJ, Khan SM. A novel 'gene insertion/marker out' (GIMO) method for transgene expression and gene complementation in rodent malaria parasites. PLoS One. 2011; 6(12):e29289.
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3. Quezada LA, Sajid M, Lim KC, McKerrow JH. A blood fluke serine protease inhibitor regulates an endogenous larval elastase. J Biol Chem. 2012 Mar 2; 287(10):7074-83.
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4. Kaczanowski S, Sajid M, Reece SE. Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites. Parasit Vectors. 2011; 4:44.
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5. Sajid M, Robertson SA, Brinen LS, McKerrow JH. Cruzain : the path from target validation to the clinic. Adv Exp Med Biol. 2011; 712:100-15.
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6. Pollitt LC, Colegrave N, Khan SM, Sajid M, Reece SE. Investigating the evolution of apoptosis in malaria parasites: the importance of ecology. Parasit Vectors. 2010; 3:105.
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7. de Oliveira Fraga LA, Lamb EW, Moreno EC, Chatterjee M, Dvorák J, Delcroix M, Sajid M, Caffrey CR, Davies SJ. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection. BMC Immunol. 2010; 11:56.
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8. Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J Biol Chem. 2011 Jan 7; 286(1):429-40.
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9. Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH. Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. J Biol Chem. 2010 Oct 8; 285(41):31120-9.
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10. He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11; 285(24):18516-27.
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11. Atkinson HJ, Babbitt PC, Sajid M. The global cysteine peptidase landscape in parasites. Trends Parasitol. 2009 Dec; 25(12):573-81.
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12. Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH. A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell. 2009 Nov; 8(11):1665-76.
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13. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703.
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14. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8.
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15. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009; 3(6):e449.
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16. Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M, Rosenthal PJ, Brinen LS. Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem. 2009 Feb 12; 52(3):852-7.
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17. Pungercar JR, Caglic D, Sajid M, Dolinar M, Vasiljeva O, Pozgan U, Turk D, Bogyo M, Turk V, Turk B. Autocatalytic processing of procathepsin B is triggered by proenzyme activity. FEBS J. 2009 Feb; 276(3):660-8.
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18. Huang R, Que X, Hirata K, Brinen LS, Lee JH, Hansell E, Engel J, Sajid M, Reed S. The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Mol Biochem Parasitol. 2009 Mar; 164(1):86-94.
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19. Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis. 2008; 2(9):e298.
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20. Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis. 2008; 2(7):e262.
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21. Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH. Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum. Mol Biochem Parasitol. 2008 Aug; 160(2):129-37.
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22. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27; 283(26):18024-31.
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23. Doyle PS, Sajid M, O'Brien T, Dubois K, Engel JC, Mackey ZB, Reed S. Drugs targeting parasite lysosomes. Curr Pharm Des. 2008; 14(9):889-900.
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24. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58.
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25. Debnath A, Tashker JS, Sajid M, McKerrow JH. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. Int J Parasitol. 2007 Jul; 37(8-9):897-906.
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26. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun; 37(7):713-24.
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27. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. 2007 Jan; 4(1):e14.
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28. Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem. 2006 Dec 22; 281(51):39316-29.
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29. Steverding D, Caffrey CR, Sajid M. Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design. Mini Rev Med Chem. 2006 Sep; 6(9):1025-32.
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30. Walker MJ, Rylett CM, Keen JN, Audsley N, Sajid M, Shirras AD, Isaac RE. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Proteome Sci. 2006; 4:9.
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31. DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH. Giardia lamblia cysteine proteases. Parasitol Res. 2006 Sep; 99(4):313-6.
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32. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. Proteases in parasitic diseases. Annu Rev Pathol. 2006; 1:497-536.
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33. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul; 35(8):895-910.
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34. Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr; 386(4):339-49.
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35. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May; 35(6):583-9.
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36. Debnath A, Das P, Sajid M, McKerrow JH. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 1; 190(3):448-57.
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37. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7.
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38. Caffrey CR, McKerrow JH, Salter JP, Sajid M. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8.
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39. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75.
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40. Mottram JC, Helms MJ, Coombs GH, Sajid M. Clan CD cysteine peptidases of parasitic protozoa. Trends Parasitol. 2003 Apr; 19(4):182-7.
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41. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80.
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42. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61.
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43. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105.
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44. Sajid M, McKerrow JH. Cysteine proteases of parasitic organisms. Mol Biochem Parasitol. 2002 Mar; 120(1):1-21.
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45. Taylor HM, Triglia T, Thompson J, Sajid M, Fowler R, Wickham ME, Cowman AF, Holder AA. Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated. Infect Immun. 2001 Jun; 69(6):3635-45.
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46. Gunaratne RS, Sajid M, Ling IT, Tripathi R, Pachebat JA, Holder AA. Characterization of N-myristoyltransferase from Plasmodium falciparum. Biochem J. 2000 Jun 1; 348 Pt 2:459-63.
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47. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8.
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48. Sajid M, Withers-Martinez C, Blackman MJ. Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease. J Biol Chem. 2000 Jan 7; 275(1):631-41.
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49. Withers-Martinez C, Carpenter EP, Hackett F, Ely B, Sajid M, Grainger M, Blackman MJ. PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome. Protein Eng. 1999 Dec; 12(12):1113-20.
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50. Hackett F, Sajid M, Withers-Martinez C, Grainger M, Blackman MJ. PfSUB-2: a second subtilisin-like protein in Plasmodium falciparum merozoites. Mol Biochem Parasitol. 1999 Oct 15; 103(2):183-95.
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51. Blackman MJ, Fujioka H, Stafford WH, Sajid M, Clough B, Fleck SL, Aikawa M, Grainger M, Hackett F. A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites. J Biol Chem. 1998 Sep 4; 273(36):23398-409.
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52. Isaac RE, Schoofs L, Williams TA, Corvol P, Veelaert D, Sajid M, Coates D. Toward a role for angiotensin-converting enzyme in insects. Ann N Y Acad Sci. 1998 May 15; 839:288-92.
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53. Isaac R, Schoofs L, Williams TA, Veelaert D, Sajid M, Corvol P, Coates D. A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide. Biochem J. 1998 Feb 15; 330 ( Pt 1):61-5.
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54. Lamango NS, Sajid M, Isaac RE. The endopeptidase activity and the activation by Cl- of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an an angiotensin-converting enzyme from the housefly, Musca domestica. Biochem J. 1996 Mar 1; 314 ( Pt 2):639-46.
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55. Sajid M, Keating C, Holden-Dye L, Harrow ID, Isaac RE. Metabolism of AF1 (KNEFIRF-NH2) in the nematode, Ascaris suum, by aminopeptidase, endopeptidase and deamidase enzymes. Mol Biochem Parasitol. 1996 Jan; 75(2):159-68.
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56. Sajid M, Isaac RE. Identification and properties of a neuropeptide-degrading endopeptidase (neprilysin) of Ascaris suum muscle. Parasitology. 1995 Dec; 111 ( Pt 5):599-608.
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57. Sajid M, Isaac RE. Metabolism of AF1 (KNEFIRF-NH2) in the nematode Ascaris suum. Biochem Soc Trans. 1994 Aug; 22(3):293S.
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