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Primary tabs

1. Personal Information

Barry Bunin
My web page
Collaborative Drug Discovery, Inc.

2. Community Expertise

Malaria research
Schistosomiasis research
The Synaptic Leap community

3. Publications


Perspectives, compilations, and reviews of modern drug discovery methods:

Bunin, B. A.; Bajorath, J.; Morales, G.; Siesel, B. Cheminformatics: Theory, Practice, and Products 2006, Springer-Verlag, manuscript in press, A summary of the theory and features of the available modern cheminformatics tools.

Bunin, B. A. Increasing the Efficiency of Small Molecule Drug Discovery (In response to an interview with Chris Lipinski on current challenges) Drug Discovery Today 2003, 8, 18, 823-826.

Bunin, B. A.; Dener, J. M.; Livingston, D. A. Application of Combinatorial and Parallel Synthesis to Medicinal Chemistry Annu. Rep. Med. Chem. 1999, 34, 267-286.

Bunin, B. A. The Combinatorial Index 1998, pp. 1-322, Academic Press, An exhaustive compilation on methods for the combinatorial synthesis of small molecules widely used by synthetic chemists.

Morales, G. A.; Bunin, B. A. Guest Editors, Comb. Chem. & HTS., 2004, 7, 5. 397-529.

Morales, G. A.; Bunin, B. A. Editors, Methods Enzymol., 2003, 369, Combinatorial Chemistry Part B, pp. 1-569.

Primary scientific literature and patents:

Smyth, M. S.; Laidig, G. J; Borchardt, R. T.; Bunin, B. A.; Crews, C. M.; Musser, J. H.; Schneekloth, J. S.; Chabala, J. C. Compounds for Enzyme Inhibition. Patent No. US 2005/0245434 A1; issued 3 Nov 2005 (Proteolix, Inc).

Bunin, B. A.; Dener, J. M.; Kelly, D. E.; Paras, N. A.; Tario, J. D.; Tushup, S. P. Solid-Phase Synthesis of 1-Substituted Tetrahydroisoquinoline Derivatives Employing BOC-Protected Tetrahydroisoquinoline Carboxylic Acids J. Comb. Chem. 2004, 6, 487-496.

Bryant, C.; Bunin, B. A.; Kraynack, E. A.; Patterson, J. W. Compounds and Compositions as Protease Inhibitors. US Patent No. 6,455,502; issued Sept 2002 (Axys Pharmaceuticals).

Ramdas, L.; Bunin, B. A.; Plunkett, M. J.; Sun, G.; Ellman, J. A.; Gallick, G.; Budde, R. J. A. "Benzodiazepine Compounds as Inhibitors of the Src Protein Tyrosine Kinase: Screening of a Combinatorial Library of 1,4-Benzodiazepines" Archives of Biochem. And Biophys. 1999, 368, 394-400.

Bunin, B. A.; Plunkett, M. J.; Ellman, J. A.; Bray, A. M. "The Synthesis of a 1680 Member 1,4-Benzodiazepine Library" New J. Chem. 1997, 21, 125-130.

Stevens, S. Y.; Bunin, B. A..; Plunkett, M. J.; Swanson, P. C.; Ellman, J. A.; Glick, G. "Non-Nucleic Acid Inhibitors of Protein-DNA Interactions Identified Through Combinatorial Chemistry" J. Am. Chem. Soc. 1996, 118, 10650-10651.

Bunin, B. A.; Plunkett, M. J.; Ellman, J. A. "Synthesis and Evaluation of 1,4-Benzodiazepine Libraries" Methods Enzymol., 1996, 267, 448-465.

Bunin, B. A.; Plunkett, M. J.; Ellman, J. A. "The Synthesis and Evaluation of Three 1,4-Benzodiazepine Libraries" In Peptide and Nonpeptide Libraries: A Handbook for Chemists, Jung, G., Ed. 1996, Springer-Verlag.

Bunin, B. A.; Plunkett, M. J.; Ellman, J. A. "The Combinatorial Synthesis and Chemical and Biological Evaluation of a 1,4-Benzodiazepine Library" Proc. Natl. Acad. Sci. USA, 1994, 91, 4708-4712.

Bunin, B. A.; Ellman, J. A. Increasing the Diversity of a 1,4-Benzodiazepine Library through Side-Chain Functionalization Polym. Prepr. 1994, 35, 983.

Bunin, B. A.; Ellman, J. A. A General and Expedient Method for the Solid-Phase Synthesis of 1,4-Benzodiazepine Derivatives J. Am. Chem. Soc. 1992, 114, 10997-10998.


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