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Serological evidence for transmission of multiple dengue virus serotypes in Papua New Guinea and West Papua prior to 1963

PLoS Neglected Tropical Diseases News - 24 April 2017 - 9:00pm

by Dagwin Luang-Suarkia, Timo Ernst, Michael P. Alpers, Ralph Garruto, David Smith, Allison Imrie

Little is known about the natural history of dengue in Papua New Guinea (PNG). We assessed dengue virus (DENV)-specific neutralizing antibody profiles in serum samples collected from northern and southern coastal areas and the highland region of New Guinea between 1959 and 1963. Neutralizing antibodies were demonstrated in sera from the northern coast of New Guinea: from Sabron in Dutch New Guinea (now known as West Papua) and from four villages in East Sepik in what is now PNG. Previous monotypic infection with DENV-1, DENV-2, and DENV-4 was identified, with a predominance of anti-DENV-2 neutralizing antibody. The majority of positive sera demonstrated evidence of multiple previous DENV infections and neutralizing activity against all four serotypes was detected, with anti-DENV-2 responses being most frequent and of greatest magnitude. No evidence of previous DENV infection was identified in the Asmat villages of the southern coast and a single anti-DENV-positive sample was identified in the Eastern Highlands of PNG. These findings indicate that multiple DENV serotypes circulated along the northern coast of New Guinea at different times in the decades prior to 1963 and support the notion that dengue has been a significant yet neglected tropical infection in PNG for many decades.

Cystic and alveolar echinococcosis: Successes and continuing challenges

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Christine M. Budke, Adriano Casulli, Peter Kern, Dominique A. Vuitton

The role of 'omics' in the quest to eliminate human filariasis

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Sara Lustigman, Alexandra Grote, Elodie Ghedin

Parasite genomics—Time to think bigger

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Carlos Talavera-López, Björn Andersson

How to determine if a model is right for neglected tropical disease decision making

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Bruce Y. Lee, Sarah M. Bartsch

Mathematical and computational modeling can transform decision making for neglected tropical diseases (NTDs) if the right model is used for the right question. Modeling can help better understand and address the complex systems involved in making decisions for NTD prevention and control. However, all models, modelers, and modeling are not the same. Thus, decision makers need to better understand if a particular model actually fits their needs. Here are a series of questions that a decision maker can ask when determining whether a model is right for him or her.

Human African trypanosomiasis control: Achievements and challenges

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Serap Aksoy, Phillipe Buscher, Mike Lehane, Philippe Solano, Jan Van Den Abbeele

Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa. Since the beginning of the 20th century, there have been multiple HAT epidemics in sub-Saharan Africa, with the most recent epidemic in the 1990s resulting in about half a million HAT cases reported between 1990 and 2015. Here we review the status of HAT disease at the current time and the toolbox available for its control. We also highlight future opportunities under development towards novel or improved interventions.

Progress and projections in the program to eliminate trachoma

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Paul M. Emerson, Pamela J. Hooper, Virginia Sarah

<i>PLOS Neglected Tropical Diseases</i>: Ten years of progress in neglected tropical disease control and elimination … More or less

PLoS Neglected Tropical Diseases News - 20 April 2017 - 9:00pm

by Peter Hotez, Serap Aksoy

This year PLOS Neglected Tropical Diseases (PLOS NTDs) celebrates its tenth anniversary following the publication of the first issue in 2007 [1]. When PLOS NTDs was founded, the framework of the neglected tropical diseases (NTDs) as an alternative to “other diseases” (as they were then referred to in the Millennium Development Goals) was just getting started—especially for Africa [2, 3]. In the decade since, PLOS NTDs has overseen enormous successes in NTD control and elimination. Here, we want to briefly review the ten year progress made towards the control or elimination of the diseases now identified by the WHO as NTDs. Many of the details are highlighted in PLOS NTDs papers cited here, but the summary information is based on the recently released Global Burden of Disease (GBD) Study 2015 (also launched with Gates Foundation support) that summarized past-decade changes in disease prevalence, mortality, or disability rates (from the years 2005 to 2015) [4–6], as well as the GBD Study 2013 that summarizes disease prevalence changes over a longer time horizon from 1990 to 2013 [7].