Results

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02 Oct

First research update: Introductions, arrylpyrroles and sulfonates.

Published by Matin

Hello all,
I just wanted to introduce myself, I'm Matin and I started at the Todd lab in Sydney at the end of July and after 2 months I'm doing my first update on Synaptic Leap, I'll be talking about experiments which have been recorded in my lab book which can be found here.
 

31 Jul

Pharmacokinetics

Published by pylioja

Subject 

Results

Previously, we found that we had no efficacy for the compounds tested in our  in vivo plasmodium berghei study. Until now we haven't had our pharmacokinetic to figure out why this was. We had previously found that OSM-S-5 (PMY 10-6/TCMDC-123812) is rapidly metabolised in mouse plasma, but that it is stable in human plasma.

Consultation Outcome

Published by pylioja on 26 July 2012 - 6:59am

Subject 

Results

Firstly, thanks for coming to the online meeting. I found it worked quite well (minor glitches aside) but it would be great to hear your thoughts. We'll post the recording up in the near-ish future. The OpenWetWare wiki will soon be updated to reflect the outcomes of the meeting, along with SMILES. Of course if anyone is keen and beats me to it, then even better.

24 Jul

A quick compound update

Published by pylioja

Subject 

Results

Tomorrow we will be having an open chat with anyone who wants to pitch in about which compounds we should be making for the next round of testing. We've been talking about this for a while (phase 1, phase 2) and this the final call before we split some of the compounds into seperate jobs that teams can take on. In the mean time, I've made a few of the compounds we mentioned and I'm most of the way to a couple of others.

21 Jun

June 2012 update on two potential drug candidates from the Todd group

Published by JimCronshaw

Jim Cronshaw from the Todd group at the University of Sydney here again. It’s been quite some time since I made an update on my research on The Synaptic Leap. This post is intended to give an overview of what problems have been hounding me over the intervening two months.

Open Source Drug Discovery for Malaria Meeting - Session 2, Part 1, Richard Jefferson

Published by MatTodd on 23 May 2012 - 12:41am

Subject 

Results

Part of the second session at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Richard Jefferson, Cambia and the Institute of Open Innovation.

 

Late Stage Gametocyte Assay for Arylpyrroles

Published by MatTodd on 7 May 2012 - 2:13pm

Subject 

Results

Four of the arylpyrroles/near neighbors have been tested in a late stage anti-gametocyte imaging assay, with interesting results.

hERG Assay for Two Potent OSM-S Compounds

Published by MatTodd on 7 May 2012 - 1:26pm

Subject 

Results

One of the most potent compounds identified to date in the OSDD malaria project, the near-neighbour analog OSM-S-35 (ZYH3) was subjected to the hERG assay along with one of the original TCAMS GSK compounds which in this project has the tag OSM-S-5.

Raw data are here, plus spreadsheet here.

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