Miscellaneous

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Welcome

Published by gtaylor on 29 January 2006 - 10:46pm

Open Source Biomedical Research for the 21st Century

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Miscellaneous

Community 

general open research
25 Jun

Open Access Future Med Chem Issue

Published by MatTodd

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Miscellaneous

While this schisto community is not terribly active right now there was just published an excellent open access issue of Future Med Chem, edited by Conor Caffrey, and with articles by many of the major players in the field.

26 Feb

Sulfonamides

Published by Matin

As I alluded to at the end of my previous entry, I've been working on a way to make sulfonamides of the arryl pyrrole series for the OSDD Malaria project.

 
 
 
 
 
 
Figure 1. Examples of sulfonamides that are currently being made for testing as anti-malarials.

Compound Similarity Networks from Iain

Published by MatTodd on 11 April 2012 - 6:30am

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Miscellaneous

More fantastic work from Iain Wallace of ChEMBL, below. These are maps of active antimalarials and predicted targets, expressed as similarity maps, i.e. with an extra level of analysis added on top. This provides a very intuitive way of walking through related compounds to compare structures. How best do we use this kind of analysis - as a target guide, or as a "prediction of what to make next" guide?

Open Source Drug Discovery for Malaria Meeting - Session 1, Part 3, Luigi Palombi

Published by MatTodd on 8 April 2012 - 4:11am

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Miscellaneous

Part of the first session at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Dr Luigi Palombi, ANU.

 

Open Source Drug Discovery for Malaria Meeting - Session 1, Part 2, Mary Moran

Published by MatTodd on 8 April 2012 - 3:48am

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Miscellaneous

Part of the first session at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Dr Mary Moran, Policy Cures.

 

Open Source Drug Discovery for Malaria Meeting - Session 1, Part 1, Mary O'Kane

Published by MatTodd on 8 April 2012 - 3:26am

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Miscellaneous

Welcome address at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Professor Mary O'Kane, Chief Scientist and Engineer, New South Wales, Australia.
 

Open Source Drug Discovery for Malaria Meeting - Opening Comments

Published by MatTodd on 7 April 2012 - 1:05pm

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Miscellaneous

Opening remarks at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Dr Mat Todd, The University of Sydney.
 

Open Source Drug Discovery for Malaria Meeting - February 2012 - Why?

Published by MatTodd on 7 April 2012 - 12:47pm

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Miscellaneous

In August 2011 my lab started an open source drug discovery for malaria project. We’ve been a) very excited about this idea, and b) very busy getting things started. It’s an unusual project, exciting not only because we might be able to change the world, but because it’s not clear how we might do it. To me, that’s the definition of good research – you not only don’t know whether it’s going to work, but you don’t even know how to go about doing it.
 

09 Mar

Deuterated PZQ

Published by MatTodd

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Miscellaneous

Was alerted to this NCTT project/proposal for deuterated analogs of enantiopure PZQ, with the deuteration being used to slow metabolism. Would be interesting to see how many D's are incorporated, and where (presumably at least the 4' position). I hope they're using our resolution approach to make their enantiopure material. And I wonder what the deuteration does to the cost, on scale?
(original page http://nctt.nih.gov/27545311)

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