More fantastic work from Iain Wallace of ChEMBL, below. These are maps of active antimalarials and predicted targets, expressed as similarity maps, i.e. with an extra level of analysis added on top. This provides a very intuitive way of walking through related compounds to compare structures. How best do we use this kind of analysis - as a target guide, or as a "prediction of what to make next" guide?

Part of the first session at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Dr Luigi Palombi, ANU.

Part of the first session at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Dr Mary Moran, Policy Cures.

Welcome address at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Professor Mary O'Kane, Chief Scientist and Engineer, New South Wales, Australia.
 

Opening remarks at the Open Source Drug Discovery for Malaria meeting at The University of Sydney, February 24th 2012. Speaker is Dr Mat Todd, The University of Sydney.
 

In August 2011 my lab started an open source drug discovery for malaria project. We’ve been a) very excited about this idea, and b) very busy getting things started. It’s an unusual project, exciting not only because we might be able to change the world, but because it’s not clear how we might do it. To me, that’s the definition of good research – you not only don’t know whether it’s going to work, but you don’t even know how to go about doing it.