schisto research community

content appropriate for schistosomiosis research

Pictet-Spengler Route to (R)-PZQ

Published by MatTodd on 29 November 2007 - 1:21pm

The Pictet-Spengler reaction is used in the current industrial synthesis of rac-PZQ, and these reactions have been looked at on the Synaptic Leap here.
The PS has been used in the synthesis of PZQ, and we used it as the final step in our solid phase synthesis of PZQ, but both these syntheses were racemic.
Catalytic, asymmetric

Starting from the Racemate

Published by MatTodd on 29 November 2007 - 12:15pm

There are two general ways to generate enantioenriched PZQ starting from the racemate - either by destroying the stereocentre, or not.


Published by MatTodd on 29 November 2007 - 11:47am
01 Nov

GemIdent - color image segmentation software

Published by way4thesub

Hi all,


I would like to introduce my open-source project at Stanford, GemIdent:


GemIdent specializes in color image segmentation using supervised machine learning. For example, you can use it to locate and count cells in microscopic images:

Promising Targets for Schistosomiasis

Published by MatTodd on 22 October 2007 - 11:56pm

Possible molecular targets for schisto research should be child pages off this one.

Thioredoxin Glutathione Reductase

Published by MatTodd on 22 October 2007 - 10:11pm

A recent paper suggests that thioredoxin glutathione reductase from S. mansoni is an interesting drug target for schisto, particularly given that PZQ was inactive against this target. From a quick look at the paper it appears as though no crystal structure is available for the enzyme, but screening is required. I wonder: is there anything the community can do here as a research project in virtual screening, given the data in the paper on compounds already tested? Mat