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schisto news feeds
- A convenient and highly stereoselective synthesis of 14-substituted 8,13-diazaoestrone analogues by domino ring closures
- The NIH-NIAID Schistosomiasis Resource Center
- Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure
- High excretion of etheno adducts in liver fluke-infected patients: protection by praziquantel against DNA damage
- The Anthelmintic Activity of the Cyclotides: Natural Variants with Enhanced Activity
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Schistosomiasis Research Community
Welcome, I'm Mat Todd, the community leader for schistosomiasis research.
Why Schistosomiasis is Important
Schistosomiasis is one of the most burdensome of the neglected diseases, with 200 million people infected and 400 million people at risk. Infection is widespread with a relatively low mortality rate, but a high morbidity rate, causing severe debilitating illness in millions of people. The disease is often associated with water resource development projects, such as dams and irrigation schemes, where the snail intermediate hosts of the parasite breed. The drug of choice for the treatment of schistosomiasis is praziquantel (PZQ).
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As a guest on The Synaptic Leap, you can browse and look all you want. You must login and create a user profile for yourself if you want to participate. Once you are logged in you may begin collaborating with other scientists world-wide and become a part of the collective intelligence trying to help improve the drugs available for schisto.
Get Involved with an Open Research Project
See current projects for a list of our active open research projects. You may learn more about these projects and learn how you can participate. Or, you may "add a child page" (see the link at the bottom) to initiate and describe your own open research project for schistosomiasis.
If you're still in the brainstorming phase of starting a project, write a blog article to discuss your ideas with other scientists around the world also studying schistosomiasis. Working together, we can direct the research towards the most promising ideas.
You can also help shape and direct other schisto research ideas by reading and commenting on other community posts.
Keep Up To Date with The Latest Schisto Information
To assist you with your schisto research we have pulled together a research tools page for schisto as well as an RSS news feeds for schisto. If you know of a useful tool that we don't have on the list, login and add a comment for others to see.
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Pictet-Spengler route to (R)-PZQ?
Dear Mat
What about forming the isoquinoline ring using a chiral phenylethanolamine? The standard isoqunoline formation from phenylethylamines and aldehydes is called the Pictet-Spengler Isoquinoline Synthesis, and you can find reviews at Organic Reactions v6, p151 (1951) and J. Heterocycl. Chem. v8, p1007 (1971). We have done this reaction on phenylephrine with a variety of aldehydes and it works very well and gives good chiral induction. Both (R) and (S) 2-amino-1-phenylethanol are commercially available. Although they are very expensive from Aldrich, a couple of suppliers do claim to sell the material in bulk. Not sure if this will ever rival the cost of using praziquantel itself as the starting material as recently suggested by Craig but it might make an interesting project anyway.
Regards
Wayne
Everyone loves the PS!
Nice idea, Wayne. Since this is a new route, I'm going to start a new thread here.
Cheers,
Mat