Our Resources Needed page aggregates all posts for volunteer and resources needed for open research projects. These resources may include lab time, materials, CPU cycles computations - whatever is needed to move an open research project forward. If you are interested in a particular project, login and post a comment expressing your interest.
Need Help With Your Project?
To post a request for resources for your own open research project, you may login and create a blog page with a "Subject" of Resources needed and it will automatically be added to this page. If these resources are related to a specific project logged within TSL you can also create/associate the resource request page as a "child page" to your project page. This will allow people to find your resolource request needs from both your project page and the resources needed menu item.
General tips for posting a resources needed page:
People generally scan the web, use bullets
Provide explicit links to pages where you have more project details should you entice them with your bullets. You can create a project page or a blog page to describe your project.
Describe what's in it for the volunteers. What will they learn, how will they help the world, what great contacts will they make?
Consider putting your email information directly on the post. I know that they can always post comments to find out more. But I've seen a big hesitancy in doing that. People are far more open with email.
As I alluded to at the end of my previous entry, I've been working on a way to make sulfonamides of the arryl pyrrole series for the OSDD Malaria project.
Figure 1. Examples of sulfonamides that are currently being made for testing as anti-malarials.
I’ve recently been doing some pharmacophore modelling of some of the OSM and GSK compounds. I was kindly given access to the Schrodinger Suit Software by Dai Hibbs in the Faculty of Pharmacy here at Sydney. Unfortunately, my previous experience with the Schrodinger software is rather limited and I’ve never used the Phase application before. Anyway, I set about getting used to the software again watching all the online tutorials and reading the manuals. After getting used to the software a nice trend in the data was found and I set about tuning this model. Unfortunately this is where I’
Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)
Hello, I’m Alice and I joined Mat Todd’s group as a Postdoc just over a month ago. I have started working on the Malaria open source drug discovery project and this is the first of many posts to come, thanks for reading and please let me know your thoughts. My first task was to synthesise compound Sd a fairly unintimidating target, especially as Paul Ylioja has developed a robust synthesis of the required alcohol 1.
Hello all,
I just wanted to introduce myself, I'm Matin and I started at the Todd lab in Sydney at the end of July and after 2 months I'm doing my first update on Synaptic Leap, I'll be talking about experiments which have been recorded in my lab book which can be found here.
Analogues of the amino thienopyrimidine lead compound are needed to assess structure-activity relationship's (SAR's) of the compound. To acheive this, both novel synthetic compounds and commercially available compounds must be obtained and submitted for biological screening. The novel synthetic compounds are being synthesised in the Todd lab at the University of Sydney. The commercially available compounds were identified by performing a similarity search on eMolecules using a similarity (Tanimoto) co-efficient of 0.55.
The evaluation of the arylpyrroles has gone well, in that we've identified promising new antimalarial compounds. Besides their high potency, they exhibit high levels of activity in a late-stage gametocyte assay which is very exciting.
