Biological Results for Third Set of Compounds
Community
malaria research communitySubject
ResultsA summary of the biological activities obtained for the third set of compounds in 2012 - those arising from the consultation for which synthetic and commercial compounds that were most wanted. See also some links for analysis of trends in the data.
First set (Oct 19th) Data, and these were discussed briefly in an online meeting.
Second set (Nov 8th) Data, and discussion
Third set (Dec 10) Data (essentially inactive, aside from mild activity for OSM-S-103
Previous discussion of these data, highlighting trends.
Importance of primary amide side chain.
Impact of replacing ester with amides and amines. And impact on the two original GSK compounds.
Dramatic impact of methylation of the hit compound.
Reminder of the efficacy of the near neighbour thiazolidinones.
Suggestion of next compounds, including hybrids, and the WANTED! compounds.