Role of Calcium Flux

Published by MatTodd on 1 June 2008 - 9:31pm

Another interesting PZQ paper has come out of the cell biology group at the CNR in Rome, concerning the mode of action of PZQ. Using radioactive calcium, the group have demonstrated that calcium influx in itself is not enough to kill parasites. Pre-incubation with cytochalasin D promoted calcium influx but protected the worms from PZQ's schistosomicidal effects.