Published by MatTodd on 22 October 2007 - 10:05pm

Does praziquantel bind actin? Tallima and El Ridi recently proposed actin as the molecular target of PZQ, based on affinity chromatography studies. Todd and Cioli performed similar experiments (with a different support-bound PZQ) and found actin bound to PZQ-free support, implying that actin is a false positive, identified due to its cellular abundance. Other evidence? Required projects?