Comparative Modeling of proteins in the Malaria genome

Published by marcius on 2 December 2005 - 2:50am
This project is completed.

The functional characterization of protein sequences is central to problems in biology. This task is usually facilitated by an accurate three-dimensional (3D) structure of the protein of interest. In the absence of an experimentally determined structure, comparative or homology modeling can provide a useful 3D model for a protein that is related to at least one known structure. The Sali group at UCSF has used the ModPipe software to build models for as many as possible ORFs in the Malaria genome. This has resulted in 10,743 three-dimensional models of 3,321 genes in the malaria genome (63% of all annotated ORF). To visualize the result of this project, you can visit the Gene Card project page. Alternatively, models can also be directly accessed in the ModBase database by selecting the tdi_malaria set of models. The data generated by ModPipe and deposited either in this site or the ModBase database is freely available for non-commercial propouses.

Please, cite this two articles if you use any of the data generated by ModPipe
  • Pieper, U. et al. Nucleic Acids Research 32, D217-D222, 2004
  • Eswar, N. et al. Nucleic Acids Research 31, 3375-3380, 2003