malaria research community

content appropriate for malaria research community

07 Apr

KILLING MOSQUITO LARVAE -- try cinnamon oil

Published by rayonsoleil

Subject 

External News

The material below is from a press release issued in July 2004 by the American Chemical Society.

And as a side note --cinnamon oil contains2-phenylacetaldehyde.

Witch hazel (Hamamelis virginiana) contains acetaldehyde. Therefore one wonders if witch hazel poured onto watery places where mosquitoes might breed, whether it wouldact as a larvicide too.

[ En francais -- Le matériel ci-dessous, c'est un communiqué de presse publié juillet 2004 par la société chimique américaine.

27 Mar

Giving help and support

Published by tiago

Hi!

First, introductions: I am a PhD student in Bioinformatics (BsC in Computer Science, MSc in Bioinformatics. Thesis topic in selection detection). Contrary to most PhD students I happen to have some free time that I would like to use in "useful" science.

After having seen this highly inspirational video about open source drug discovery I decided that the free time I have would be spent around what I've seen on that video. Although my area of PhD is a bit different, I had courses in computational drug design and proteomics, so I have a general overview of the area (in fact most examples given were, fortunately, around Malaria). My strong point (what I can offer) is software development coupled with some knowledge of Chemistry and Biology.

I am checking the community site for a few days from now and is never functional. Is it possible to put it back on? Or better yet, point where some communities around open source Bioinformatics applied to Malaria are alive? Or projects needing computer scientists willing to give their free time to this?

Many thanks to whoever reads this,
Tiago

23 Mar

Ideas on disappearing furan in TFA?

Published by jcbradley

We have a problem in synthesizing our anti-malarials that could use some feedback from some organic chemists:

Ever since we isolated our Ugi products, we've been trying to cyclize them to the diketopiperazines. As described by Hulme, we are trying to effect an intramolecular transamidation catalyzed by trifluoroacetic acid (TFA). Instead of dichloroethane we are generally using CDCl3 so that we can monitor the reaction by NMR.

The first step of removing the boc group seems to proceed very smoothly, with the appearance of t-butyl trifluoroacetate at 1.61 ppm within a few minutes or hours, depending on the concentration of TFA. Here is a H NMR from Khalid's EXP070, 13 min after addition of 50% TFA in CDCl3 showing complete deprotection:

23 Mar

TDR Publication "Lessons learned in Home Management of Malaria..."

Published by gtaylor

Subject 

External News

TDR has just produced the following new publication:

Lessons learned in Home Management of Malaria -
Implementation research in four African countries
http://www.who.int/tdr/publications/publications/lessons_hmm.htm

Functional Reconstitution of the Plasmodium GPI:protein transamidase Complex

Published by Saj on 22 March 2007 - 7:23pm

Proteins that have a GPI glycolipid modification are acknowledged to be key in the lifecycle of Plasmodium; for example the involvement of the GPI-anchored MSP1 on merozoites in erythrocyte invasion.  The enzyme that transfers the preformed GPI to the proteins such as MSP1 is named GPI:protein transamidase, however, studying this enzyme biochemically has been arduous, due to the following hurdles.

20 Mar

New PAHO publication on Malaria (message from TDR)

Published by gtaylor

I subscribe to the TDR news letter. Here's a recent email they sent me. Also notice that there's a link for subscription instructions if you too would like regular notes from them. I don't get too many - maybe 2 a month.

 

-------------------------------------------------------------------
-for tropical disease researchers & friends: "tdr-scientists list"
-------------------------------------------------------------------

       New PAHO publication on Malaria

For info,

The Pan American Health Organization (PAHO) has issued a new publication
called: The Regional Strategic Plan for Malaria in the Americas,
2006-2010 [pdf 2.4 MB - long to download].

This report is downloadable from:
http://www.paho.org/English/AD/DPC/CD/mal-reg-strat-plan-06.pdf

For more information please contact Ms Mylena Pinzon, PAHO Publications
Program at mailto:dissemination@paho.org

Please do not contact TDR.

--
Sharing news with the t.d.r. community, mailto:tdr-scientists@who.ch To unsubscribe, or subscribe, write to:Â owner-tdr-scientists@who.ch News on UNDP/WorldBank/WHO-TDRÂ http://www.who.int/tdr/topmenu/news/
Â

07 Jan

Collaborative Drug Discovery UCSF/QB3-Hosted First Annual Community Users Meeting Agenda

Published by BarryBunin

Subject 

External News

Dear TSL Members,

 

You are invited to the first annual QB3-UCSF-CDD developing world disease research community meeting scheduled for March 5th 2007 at the UCSF Mission Bay Campus (details below and attached).  The collaborative community includes leading experts on developing world infectious disease research from Stanford, UCSF, UC Berkeley, UCLA, UW, SBRI, St. Jude CRH, U. Penn, Univ. of Sydney, and industry too.  

 

Collaborative Drug Discovery
First Annual Community Meeting

 

Monday, March 5th 2007 1:00-6:00 pm; Auditorium: J. David Gladstone Institute (1st Floor)

Hosted by Gladstone Institute and QB3 at the UCSF, Mission Bay Campus

Two major themes of this event are:

1)      Public-Private-Partnerships for Global Health Issues
2)      “Open” concepts for Collaborative Drug Discovery

Confirmed Speakers:
 

  • Dr. Christopher Lipinski, Pfizer, retired. (Keynote presentation)
  • Jim McKerrow, Professor, Dept. of Pathology, QB3 - UCSF
  • Matt Bogyo, Professor, Dept. of Pathology, Stanford Medical School
  • Andrej Sali, Professor, Dept of Biopharmaceutical Sciences, QB3 - UCSF
  • Dr. Anang Shelat, St. Jude Children’s Research Hospital
  • David Roos, Biology Professor, Univ. of Penn tentatively confirmed (Director, Penn Genomics Institute).

Symposium – Coffee/Snacks – Demos – Posters – Networking – Wine Reception

Registration is free. To register contact/RSVP to: kgregory@collaborativedrug.com.

14 Jun

Site Level Email Subscriptions

Published by gtaylor

Configuring Your Subscription

You may choose to have daily email notifications sent to you from The Synaptic Leap. You must have a registered account first. Once you have have registered and are logged in, you can go to your personal user profile and hit the "my notify settings" tab. From there, you just enable the various buttons.

I configured my settings so that I get a headline, teaser and link for all new comments and articles posted on the site.

click the image to see a full size screen shot of

If no new posts are made, no email is sent. If multiple posts are made, you only receive one email summarizing the posts with links to each post. The email that is generated also includes a link back to your personal notification settings so that you can easily disable it anytime should you ever wish to.

Open Source Article Now Online

Published by MatTodd on 13 June 2006 - 1:20pm

The article on open source written by members of TSL is now online, and may be accessed here. The article is published in the Australian Journal of Chemistry, and the publishers (CSIRO, Australia) have agreed to provide the article as open access, so no subscription is required to download it.

We'd all be very interested in feedback and ideas on the very general points mentioned.

Cheers,

Mat

 

Subject 

Miscellaneous

Forums 

Q&A and Feedback
29 May

Jean-Claude's Reactions

Published by MatTodd

Subject 

Request for Help

Jean-Claude Bradley and his team over at UsefulChem have been having a go at two reactions that have relevance to generating drug candidates for malaria. Organic chemists should check out the site if they feel they can help with what's going on. The two reactions are firstly the conversion of adrenaline to catechol aldehyde:

UsefulChem Adrenaline Conversion

and secondly the Ugi synthesis of a DKP along the following lines:

 

UsefulChem DKP Ugi

The resources needed are your input into how to make these reactions go! The Usefulchem team are making good use of YouTube video feeds to provide extra information on what's going on with their attempts.

Cheers,

Mat

 

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