malaria research community

content appropriate for malaria research community

Availability of TCMDC-123812 and TCMDC-123794

Published by MatTodd on 27 August 2011 - 11:51am

We're starting open source drug discovery for malaria. We have to start somewhere: in this case a couple of known compounds that showed good activity and have plenty of possibilities for modification - compounds contained in the open deposition of malaria data from 2010, originating from GSK's Tres Cantos lab.

Proposed resynthesis strategy for TCMDC-123812 and TCMDC-123794

Published by pylioja on 18 August 2011 - 5:08am

Below is a proposed synthesis strategy to the two members of the TCMDC aryl pyrrole series. Please comment, give your thoughts and improvements.
Experimental attempts are documented on an electonic lab notebook found here:
Proposed synthesis strategy

Open Source Drug Discovery: The GSK Arylpyrrole Series

Published by MatTodd on 25 July 2011 - 11:21am

Several labs are leading an open source drug discovery project for malaria, including the Todd lab at the University of Sydney, the Medicines for Malaria Venture and GSK Tres Cantos, but the project requires many other partners. The aim is to prosecute a hit-to-lead campaign starting from known actives in the GSK data set. Some background is here.

The Drug Development Process

Published by ndt228 on 2 May 2010 - 7:01pm



There may be members of this community who do not yet have direct experience of developing a new medicine from concept to pharmacy shelf.  Be assured, there is a lot more to it than "just" the synthesis of the API.  Why not take advantage of a Free ACS Webcast on May 6, 2010 Thurs 2:00-3:00 PM ET
From a Beaker to a Bottle: Overview of the Drug Discovery and Development Process for Small Molecule Therapeutics

23 Aug

Chloroquine prophylaxis protects against malaria -

Published by Saj

 100% protective malaria vaccine 
Administering chloroquine before being exposed infected mosquitos, provides a vaccine that is 100% protective.