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06 Feb

Proposed Synthesis of 'compound 3' and 'compound 4'

Published by JimCronshaw

The following compounds have been identified as potential antimalarial drugs by GSK-Tres Cantos.
Target Molecules
The top compound, known hereafter as 'compound 3', can be found on ChEMBL and ChemSpider:
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL535225 - ChEMBL

06 Feb

Proposed Synthesis of 'compound 3' and 'compound 4'

Published by JimCronshaw

The following compounds have been identified as potential antimalarial drugs by GSK-Tres Cantos.
Target Molecules
The top compound, known hereafter as 'compound 3', can be found on ChEMBL and ChemSpider:
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL535225 - ChEMBL

26 Jan

near neighbours sythesis

Published by ZoeH

I've been working for six weeks now with the Todd Research Group at Sydney University as part of an undergraduate summer research program. The aim of my project is to synthesise analogues of this group of hits from the  antimalarial dataset released by GSK.

19 Jan

Reacting to the first set of biological results

Published by pylioja

Subject 

Request for Help

We have received encouraging biological results for the analogues we sent for testing before Christmas. Mat has discussed this here on TSL and on G+. Our best hit came from the "near-neighbour" compound and the original GSK hits came out slightly less active than in their original high throughput screen.

04 Nov

TCMDC-123812 and 123794 and intermediates sent to GSK Tres Cantos

Published by pylioja

 I have just packaged up TCMDC-123794 (PMY 11-2) and -123812 (PMY 10-2) along with the parent acid (PMY 8-2), ester (PMY 6-1), aldehyde (PMY 2-4), near neighbour analogue (PMY 14-1) and also the acylurea by-product (P

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