malaria research community

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10 Dec

Advice Needed: Generation of Analogues in the Thienopyrimidine Series

Published by JimCronshaw

Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)

 

05 Dec

Summary of the ArylPyrrole Data

Published by Alice Williamson

Here is a summary of the biological data obtained for the aryl pyrroles to date:

The team have been looking for patterns in the data ahead of the next consultation. The scheme below concisely displays the patterns that have been identified at this stage of the project. More detailed analysis including the structures and activities of all compounds that have been biologically evaluated can be found on the OSDD Malaria G+ page

30 Nov

First Set of Biological Results from the Third Round of Compounds

Published by Alice Williamson

 

The team set about synthesising targets SA - SJ and ordered the commercial compounds chosen at the consultation in July. In late September, the commercial compounds, plus some of the synthetic targets (and analogues) were sent away for biological evaluation.

23 Nov

Getting the SAR data out there

Published by cdsouthan

Having picked up this theme from a G+ post I have written a blog entry on aspects of getting the latest SAR data into public databases (and looking after it after its out)
http://cdsouthan.blogspot.se/2012/11/getting-your-sar-data-out-there.html
 

Open Source Drug Discovery for Malaria Project Meeting Oct 19th 2012

Published by MatTodd on 27 October 2012 - 11:24am

Subject 

Results

This meeting was the first of what will become regular monthly meetings for the OSDD malaria project. Open to all, so please feel free to come along to them.

Wiki pages:
Arylpyrroles
Thienos
Triazolos

Open Source Drug Discovery for Malaria Project Meetings

Published by MatTodd on 27 October 2012 - 11:13am

Subject 

Results

Project meetings for the Open Source Drug Discovery for Malaria project will be held in the public domain. Meetings will be linked below, with uploads to YouTube. Open to all interested.

17 Oct

Patent structures as reference compounds

Published by cdsouthan

Subject 

Request for Help

The recent small molecule anti-malarial patents review by the MMV teams is a very useful  job (http://www.citeulike.org/user/cdsouthan/article/11477246) and  the effort raises some questions.
 

08 Oct

Williamson's attempted ether synthesis

Published by Alice Williamson

Subject 

Request for Help

Hello, I’m Alice and I joined Mat Todd’s group as a Postdoc just over a month ago. I have started working on the Malaria open source drug discovery project and this is the first of many posts to come, thanks for reading and please let me know your thoughts. My first task was to synthesise compound Sd a fairly unintimidating target, especially as Paul Ylioja has developed a robust synthesis of the required alcohol 1.

02 Oct

First research update: Introductions, arrylpyrroles and sulfonates.

Published by Matin

Hello all,
I just wanted to introduce myself, I'm Matin and I started at the Todd lab in Sydney at the end of July and after 2 months I'm doing my first update on Synaptic Leap, I'll be talking about experiments which have been recorded in my lab book which can be found here.
 

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