Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)
Here is a summary of the biological data obtained for the aryl pyrroles to date:
The team have been looking for patterns in the data ahead of the next consultation. The scheme below concisely displays the patterns that have been identified at this stage of the project. More detailed analysis including the structures and activities of all compounds that have been biologically evaluated can be found on the OSDD Malaria G+ page.
The team set about synthesising targets SA - SJ and ordered the commercial compounds chosen at the consultation in July. In late September, the commercial compounds, plus some of the synthetic targets (and analogues) were sent away for biological evaluation.
This meeting was the first of what will become regular monthly meetings for the OSDD malaria project. Open to all, so please feel free to come along to them.
Project meetings for the Open Source Drug Discovery for Malaria project will be held in the public domain. Meetings will be linked below, with uploads to YouTube. Open to all interested.
Hello, I’m Alice and I joined Mat Todd’s group as a Postdoc just over a month ago. I have started working on the Malaria open source drug discovery project and this is the first of many posts to come, thanks for reading and please let me know your thoughts. My first task was to synthesise compound Sd a fairly unintimidating target, especially as Paul Ylioja has developed a robust synthesis of the required alcohol 1.
Hello all,
I just wanted to introduce myself, I'm Matin and I started at the Todd lab in Sydney at the end of July and after 2 months I'm doing my first update on Synaptic Leap, I'll be talking about experiments which have been recorded in my lab book which can be found here.
