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Insecticide-induced leg loss does not eliminate biting and reproduction in Anopheles gambiae mosquitoes

CiteULike malaria tags - 27 April 2017 - 9:23am
Scientific Reports, Vol. 7 (25 April 2017), 46674, doi:10.1038/srep46674
Alison Isaacs, Amy Lynd, Martin Donnelly
Categories: malaria news feeds

Massive introgression drives species radiation at the range limit of Anopheles gambiae

CiteULike malaria tags - 20 April 2017 - 10:50am
Scientific Reports, Vol. 7 (18 April 2017), 46451, doi:10.1038/srep46451
José Vicente, Christopher Clarkson, Beniamino Caputo, Bruno Gomes, Marco Pombi, Carla Sousa, Tiago Antao, João Dinis, Giordano Bottà, Emiliano Mancini, Vincenzo Petrarca, Daniel Mead, Eleanor Drury, James Stalker, Alistair Miles, Dominic Kwiatkowski, Martin Donnelly, Amabélia Rodrigues, Alessandra Torre, David Weetman, João Pinto
Categories: malaria news feeds

Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum

CiteULike malaria tags - 20 April 2017 - 10:06am
Genome Research (17 April 2017), gr.217356.116, doi:10.1101/gr.217356.116

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
Heather Painter, Manuela Carrasquilla, Manuel Llinás
Categories: malaria news feeds

Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition

CiteULike malaria tags - 13 April 2017 - 8:56am
J. Chem. Inf. Model., Vol. 57, No. 3. (27 March 2017), pp. 445-453, doi:10.1021/acs.jcim.6b00572

The development of new antimalarial therapies is essential, and lowering the barrier of entry for the screening and discovery of new lead compound classes can spur drug development at organizations that may not have large compound screening libraries or resources to conduct high-throughput screens. Machine learning models have been long established to be more robust and have a larger domain of applicability with larger training sets. Screens over multiple data sets to find compounds with potential malaria blood stage inhibitory activity have been used to generate multiple Bayesian models. Here we describe a method by which Bayesian quantitative structure–activity relationship models, which contain information on thousands to millions of proprietary compounds, can be shared between collaborators at both for-profit and not-for-profit institutions. This model-sharing paradigm allows for the development of consensus models that have increased predictive power over any single model and yet does not reveal the identity of any compounds in the training sets.
Andreas Verras, Chris Waller, Peter Gedeck, Darren Green, Thierry Kogej, Anandkumar Raichurkar, Manoranjan Panda, Anang Shelat, Julie Clark, Kiplin Guy, George Papadatos, Jeremy Burrows
Categories: malaria news feeds

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

CiteULike malaria tags - 12 April 2017 - 12:10pm
Malaria Journal, Vol. 16, No. 1. (5 April 2017), doi:10.1186/s12936-017-1784-1
Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Alam, Ayodhia Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad Aktaruzzaman, Nayeem Sohel, Rinzin Namgay, Tobgyel Drukpa, Surender Sharma, Elvieda Sarawati, Iriani Samad, Minerva Theodora, Simone Nambanya, Sonesay Ounekham, Rose Mudin, Garib Da Thakur, Leo Makita, Raffy Deray, Sang-Eun Lee, Leonard Boaz, Manjula Danansuriya, Santha Mudiyanselage, Nipon Chinanonwait, Suravadee Kitchakarn, Johnny Nausien, Esau Naket, Thang Duc, Ha Do Manh, Young Hong, Qin Cheng, Jack Richards, Rita Kusriastuti, Ari Satyagraha, Rintis Noviyanti, Xavier Ding, Wasif Khan, Ching Swe Phru, Zhu Guoding, Gao Qi, Akira Kaneko, Olivo Miotto, Wang Nguitragool, Wanlapa Roobsoong, Katherine Battle, Rosalind Howes, Arantxa Roca-Feltrer, Stephan Duparc, Ipsita Bhowmick, Enny Kenangalem, Jo-Anne Bibit, Alyssa Barry, David Sintasath, Rabindra Abeyasinghe, Carol Sibley, James McCarthy, Lorenz von Seidlein, Kevin Baird, Ric Price
Categories: malaria news feeds

Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation revealed by a high-resolution time course

CiteULike malaria tags - 12 April 2017 - 10:04am
bioRxiv (10 April 2017), 126276, doi:10.1101/126276

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Brandon Invergo, Mathieu Brochet, Lu Yu, Jyoti Choudhary, Pedro Beltrao, Oliver Billker
Categories: malaria news feeds

Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes

CiteULike malaria tags - 5 April 2017 - 9:41am
International Journal for Parasitology: Drugs and Drug Resistance, Vol. 7, No. 2. (August 2017), pp. 174-180, doi:10.1016/j.ijpddr.2017.03.001

Genetic diversity of 11gene-targets of new antimalarial compounds was investigated. Genetic data was analysed for 18 malaria endemic countries. No signals of selective pressure was observed. A mutation linked to resistance to a new antimalarial was found in African parasites. Amino-acid changes close to reported antimalarial resistant mutations were detected. Drug resistance is a recurrent problem in the fight against malaria. Genetic and epidemiological surveillance of antimalarial resistant parasite alleles is crucial to guide drug therapies and clinical management. New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using ∼2000 Plasmodium falciparum genome sequences, we investigated the genetic diversity of eleven gene-targets of promising antimalarial compounds and assessed their potential efficiency across malaria endemic regions. We determined if the loci are under selection prior to the introduction of new drugs and established a baseline of genetic variance, including potential resistant alleles, for future surveillance programmes.
Ana Gomes, Matt Ravenhall, Ernest Benavente, Arthur Talman, Colin Sutherland, Cally Roper, Taane Clark, Susana Campino
Categories: malaria news feeds

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