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Artemisinin and Chinese Medicine as Tu Science

CiteULike malaria tags - 13 October 2017 - 5:00pm
In Endeavour, Vol. 41, No. 3. (2017), pp. 127-135, doi:10.1016/j.endeavour.2017.06.005

The story of discovery of artemisinin highlights the diversity of scientific values across time and space. Resituating artemisinin research within a broader temporal framework allows us to understand how Chinese drugs like qinghao came to articulate a space for scientific experimentation and innovation through its embodiment of alternating clusters of meanings associated with tu and yang within scientific discourse. Tu science, which was associated with terms like native, Chinese, local, rustic, mass, and crude, articulated a radical vision of science in the service of socialist revolutionary ideals. Yang science, which signified foreign, Western, elite, and professional, tended to bear the hallmarks of professionalism, transnational networks in education and training, and an emphasis on basic or foundational research. With respect to medical research, the case of artemisinin highlights how the constitution of socialist science as an interplay of tu and yang engendered different scientific values and parameters for scientific endeavor. Modern medical research in Maoist China could harness the productive energies of mass participation to technical expertise in its investigations of Chinese drugs, and under the banner of tu science, it became possible and scientifically legitimate to research Chinese drugs in ways that had previously provoked resistance and controversy. © 2017 Elsevier Ltd
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Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing data

CiteULike malaria tags - 5 October 2017 - 2:14pm
Bioinformatics (22 August 2017), doi:10.1093/bioinformatics/btx530
Sha Zhu, Jacob Almagro-Garcia, Gil McVean
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Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria

CiteULike malaria tags - 2 October 2017 - 8:19pm
Science, Vol. 357, No. 6358. (29 September 2017), pp. 1399-1402, doi:10.1126/science.aan5478
Sibao Wang, André Dos-Santos, Wei Huang, Kun Liu, Mohammad Oshaghi, Ge Wei, Peter Agre, Marcelo Jacobs-Lorena
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Changes in the microbiota cause genetically modified Anopheles to spread in a population

CiteULike malaria tags - 2 October 2017 - 8:18pm
Science, Vol. 357, No. 6358. (29 September 2017), pp. 1396-1399, doi:10.1126/science.aak9691
Andrew Pike, Yuemei Dong, Nahid Dizaji, Anthony Gacita, Emmanuel Mongodin, George Dimopoulos
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Geographic-genetic analysis of Plasmodium falciparum parasite populations from surveys of primary school children in Western Kenya

CiteULike malaria tags - 28 September 2017 - 12:48pm
Wellcome Open Research, Vol. 2 (5 September 2017), 29, doi:10.12688/wellcomeopenres.11228.2
Irene Omedo, Polycarp Mogeni, Kirk Rockett, Alice Kamau, Christina Hubbart, Anna Jeffreys, Lynette Ochola-Oyier, Etienne de Villiers, Caroline Gitonga, Abdisalan Noor, Robert Snow, Dominic Kwiatkowski, Philip Bejon
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Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

CiteULike malaria tags - 28 September 2017 - 12:07pm
eLife, Vol. 6 (26 September 2017), doi:10.7554/elife.28673
Camila França, Michael White, Wen-Qiang He, Jessica Hostetler, Jessica Brewster, Gabriel Frato, Indu Malhotra, Jakub Gruszczyk, Christele Huon, Enmoore Lin, Benson Kiniboro, Anjali Yadava, Peter Siba, Mary Galinski, Julie Healer, Chetan Chitnis, Alan Cowman, Eizo Takashima, Takafumi Tsuboi, Wai-Hong Tham, Rick Fairhurst, Julian Rayner, Christopher King, Ivo Mueller
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Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity

CiteULike malaria tags - 28 September 2017 - 10:35am
The Journal of Infectious Diseases, Vol. 216, No. 4. (15 August 2017), pp. 468-476, doi:10.1093/infdis/jix334
Sonia Agrawal, Kara Moser, Lindsay Morton, Michael Cummings, Ankita Parihar, Ankit Dwivedi, Amol Shetty, Elliott Drabek, Christopher Jacob, Philipp Henrich, Christian Parobek, Krisada Jongsakul, Rekol Huy, Michele Spring, Charlotte Lanteri, Suwanna Chaorattanakawee, Chanthap Lon, Mark Fukuda, David Saunders, David Fidock, Jessica Lin, Jonathan Juliano, Christopher Plowe, Joana Silva, Shannon Takala-Harrison
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Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome

CiteULike malaria tags - 28 September 2017 - 10:10am
Wellcome Open Research, Vol. 2 (17 July 2017), 50, doi:10.12688/wellcomeopenres.11910.1
Abdirahman Abdi, Lu Yu, David Goulding, Martin Rono, Philip Bejon, Jyoti Choudhary, Julian Rayner
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Safety and effectiveness of mass drug administration to accelerate elimination of artemisinin-resistant falciparum malaria: A pilot trial in four villages of Eastern Myanmar

CiteULike malaria tags - 21 September 2017 - 10:53am
Wellcome Open Research, Vol. 2 (6 September 2017), 81, doi:10.12688/wellcomeopenres.12240.1
Jordi Landier, Ladda Kajeechiwa, May Thwin, Daniel Parker, Victor Chaumeau, Jacher Wiladphaingern, Mallika Imwong, Olivo Miotto, Krittaya Patumrat, Jureeporn Duanguppama, Dominique Cerqueira, Benoit Malleret, Laurent Rénia, Suphak Nosten, Lorenz von Seidlein, Clare Ling, Stéphane Proux, Vincent Corbel, Julie Simpson, Arjen Dondorp, Nicholas White, François Nosten
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A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites

CiteULike malaria tags - 20 September 2017 - 9:23am
Cellular Microbiology (13 September 2017), e12789, doi:10.1111/cmi.12789
Claire Sayers, Vanessa Mollard, Hayley Buchanan, Geoffrey McFadden, Christopher Goodman
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