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The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

CiteULike malaria tags - 6 December 2018 - 11:28am
Nature Communications, Vol. 9, No. 1. (4 December 2018), doi:10.1038/s41467-018-07588-x
Lei Zhu, Jaishree Tripathi, Frances Rocamora, Olivo Miotto, Rob van der Pluijm, Till Voss, Sachel Mok, Dominic Kwiatkowski, François Nosten, Nicholas Day, Nicholas White, Arjen Dondorp, Zbynek Bozdech
Categories: malaria news feeds

Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate

CiteULike malaria tags - 6 December 2018 - 10:48am
npj Vaccines, Vol. 3, No. 1. (27 November 2018), doi:10.1038/s41541-018-0091-3
António Mendes, Isaie Reuling, Carolina Andrade, Thomas Otto, Marta Machado, Filipa Teixeira, Joana Pissarra, Nataniel Gonçalves-Rosa, Dolores Bonaparte, João Sinfrónio, Mandy Sanders, Chris Janse, Shahid Khan, Chris Newbold, Matthew Berriman, Cynthia Lee, Yimin Wu, Christian Ockenhouse, Robert Sauerwein, Miguel Prudêncio
Categories: malaria news feeds

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways

CiteULike malaria tags - 6 December 2018 - 10:41am
PLOS Pathogens, Vol. 14, No. 11. (29 November 2018), e1007436, doi:10.1371/journal.ppat.1007436
Susana Campino, Alejandro Marin-Menendez, Alison Kemp, Nadia Cross, Laura Drought, Thomas Otto, Ernest Benavente, Matt Ravenhall, Frank Schwach, Gareth Girling, Magnus Manske, Michel Theron, Kelda Gould, Eleanor Drury, Taane Clark, Dominic Kwiatkowski, Alena Pance, Julian Rayner
Categories: malaria news feeds

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

CiteULike malaria tags - 9 November 2018 - 10:11am
ACS Infectious Diseases (30 October 2018), doi:10.1021/acsinfecdis.8b00211
John White, Satish Dhingra, Xiaoyi Deng, Farah El Mazouni, Marcus Lee, Gustavo Afanador, Aloysus Lawong, Diana Tomchick, Caroline Ng, Jade Bath, Pradipsinh Rathod, David Fidock, Margaret Phillips
Categories: malaria news feeds

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development

CiteULike malaria tags - 1 November 2018 - 12:48pm
Scientific Reports, Vol. 8, No. 1. (25 October 2018), doi:10.1038/s41598-018-34078-3
Craig Duffy, Alfred Amambua-Ngwa, Ambroise Ahouidi, Mahamadou Diakite, Gordon Awandare, Hampate Ba, Sarah Tarr, Lee Murray, Lindsay Stewart, Umberto D’Alessandro, Thomas Otto, Dominic Kwiatkowski, David Conway
Categories: malaria news feeds

A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation

CiteULike malaria tags - 1 November 2018 - 11:56am
Malaria Journal, Vol. 17, No. 1. (26 October 2018), doi:10.1186/s12936-018-2532-x
Kimberly Breglio, Roberto Amato, Richard Eastman, Pharath Lim, Juliana Sa, Rajarshi Guha, Sundar Ganesan, David Dorward, Carleen Klumpp-Thomas, Crystal McKnight, Rick Fairhurst, David Roberts, Craig Thomas, Anna Simon
Categories: malaria news feeds

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

CiteULike malaria tags - 18 October 2018 - 12:03pm
Nature Communications, Vol. 9, No. 1. (12 October 2018), doi:10.1038/s41467-018-06733-w
Hanwei Fang, Ana Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise Walker, Zenon Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David Baker, Oliver Billker, Mathieu Brochet
Categories: malaria news feeds

Within-host competition can delay evolution of drug resistance in malaria

CiteULike malaria tags - 11 September 2018 - 6:40pm
PLOS Biology, Vol. 16, No. 8. (21 August 2018), e2005712, doi:10.1371/journal.pbio.2005712
Mary Bushman, Rustom Antia, Venkatachalam Udhayakumar, Jacobus de Roode
Categories: malaria news feeds

List of keywords of the INRMM meta-information database - part 23

CiteULike malaria tags - 7 September 2018 - 5:11pm
(February 2014)

List of indexed keywords within the transdisciplinary set of domains which relate to the Integrated Natural Resources Modelling and Management (INRMM). In particular, the list of keywords maps the semantic tags in the INRMM Meta-information Database (INRMM-MiD). [\n] The INRMM-MiD records providing this list are accessible by the special tag: inrmm-list-of-tags ( http://mfkp.org/INRMM/tag/inrmm-list-of-tags ).
Categories: malaria news feeds

Inducible developmental reprogramming redefines commitment to sexual development in the malaria parasite Plasmodium berghei

CiteULike malaria tags - 6 September 2018 - 10:35am
Nature Microbiology (3 September 2018), doi:10.1038/s41564-018-0223-6
Robyn Kent, Katarzyna Modrzynska, Rachael Cameron, Nisha Philip, Oliver Billker, Andrew Waters
Categories: malaria news feeds

Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution

CiteULike malaria tags - 30 August 2018 - 10:34am
PLOS Biology, Vol. 16, No. 8. (24 August 2018), e2006035, doi:10.1371/journal.pbio.2006035
Aude Gilabert, Thomas Otto, Gavin Rutledge, Blaise Franzon, Benjamin Ollomo, Céline Arnathau, Patrick Durand, Nancy Moukodoum, Alain-Prince Okouga, Barthélémy Ngoubangoye, Boris Makanga, Larson Boundenga, Christophe Paupy, François Renaud, Franck Prugnolle, Virginie Rougeron
Categories: malaria news feeds

Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia

CiteULike malaria tags - 24 August 2018 - 8:13am
Scientific Reports, Vol. 8, No. 1. (22 August 2018), doi:10.1038/s41598-018-30593-5
Duangkamon Bunditvorapoom, Theerarat Kochakarn, Namfon Kotanan, Charin Modchang, Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Thanyaluk Krasae, Liwang Cui, Kesinee Chotivanich, Nicholas White, Prapon Wilairat, Olivo Miotto, Thanat Chookajorn
Categories: malaria news feeds

Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites

CiteULike malaria tags - 23 August 2018 - 10:09am
Proceedings of the National Academy of Sciences (20 August 2018), 201810053, doi:10.1073/pnas.1810053115
Dorothy Loy, Lindsey Plenderleith, Sesh Sundararaman, Weimin Liu, Jakub Gruszczyk, Yi-Jun Chen, Stephanie Trimboli, Gerald Learn, Oscar MacLean, Alex Morgan, Yingying Li, Alexa Avitto, Jasmin Giles, Sébastien Calvignac-Spencer, Andreas Sachse, Fabian Leendertz, Sheri Speede, Ahidjo Ayouba, Martine Peeters, Julian Rayner, Wai-Hong Tham, Paul Sharp, Beatrice Hahn
Categories: malaria news feeds

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

CiteULike malaria tags - 20 August 2018 - 8:10am
Nature Communications, Vol. 9, No. 1. (17 August 2018), doi:10.1038/s41467-018-05652-0
Leila Ross, Satish Dhingra, Sachel Mok, Tomas Yeo, Kathryn Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick Fairhurst, Frederic Ariey, Didier Menard, David Fidock
Categories: malaria news feeds