The Synaptic Leap

Abstract Plasmodium falciparum chloroquine resistance (CQR) transporter point mutation (PfCRT 76T) is known to be the key determinant of CQR. . . .

ABSTRACT: BACKGROUND: Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multi-valent vaccine formulation. . . .

ABSTRACT: BACKGROUND: Plasmodium parasites are causative agents of malaria which affects >500 million people and claims ~2 million lives annually. . . .

ABSTRACT: The RTS,S/AS candidate malaria vaccine has demonstrated efficacy against a variety of endpoints in Phase IIa and Phase IIb trials over more than a decade. . . .

Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. . . .

Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. . . .

ABSTRACT: BACKGROUND: Little is known about the process of knowledge translation in low- and middle-income countries. . . .

Objective: To document overall performance and improvement, if any, gained through participation in an International External Quality Assessment Scheme (IEQAS). . . .

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design. . . .

Summary Orf virus (ORFV) is a zoonotic parapoxvirus that induces acute pustular skin lesions in sheep and humans. . . .

Severe malarial anemia is the most common syndrome of severe malaria in endemic areas. . . .

Despite recent advances in sequencing, complete finishing of large genomes and analysis of novel proteins they encode typically require cloning of specific regions. . . .

An AccQ*Tag ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (AccQ*Tag-UPLC-ESI-MS/MS) method for fast, reproducible, and sensitive amino acid quantitation in biological samples, particularly, the malaria parasite Plasmodium falciparum is presented. . . .

Placental malaria (PM), a frequent infection of pregnancy, provides an ideal opportunity to investigate the impact on immune development of exposure of the foetal immune system to foreign antigens. . . .

Treatment of Plasmodium falciparum is complicated by the emergence and spread of parasite resistance to many of the first line drugs used to treat malaria. . . .

ABSTRACT: BACKGROUND: Information on the burden of malaria in early infancy is scarce. . . .

Antibacterial peptides crustins are the effector molecules of innate immunity in decapods. . . .

Functions have yet to be defined for the majority of genes of Plasmodium falciparum, the agent responsible for the most serious form of human malaria. . . .

BACKGROUND: The T-cell mediated immune response plays a central role in the control of malaria after natural infection or vaccination. . . .

BACKGROUND: Control measures which reduce individual exposure to malaria are expected to reduce disease, but also to eventually reduce immunity. . . .