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Single crystal X-ray
Communitymalaria research community
We've just had a single crystal x-ray structure back for OSM-S-9 (PMY 35-1) confirming which isomer of the product we've been making.
The structure shows the acyl group on the N-phenyl nitrogen rather than on the iminothiazolidinone nitrogen. It's nice to have this cleared up.
We've previously collected x-ray structures of OSM-S-35 (ZYH 3-1), OSM-S-43 (ZYH 10-1-B) and OSM-S-54 (ZYH 22-3). ZYH 10-1-B and ZYH 22-3 both showed substitution on the iminothiazolidinone nitrogen. In the case of ZYH 10-1-B, the other isomer was also isolated and assigned by analogy as it did provide x-ray quality crystals.
This might be a good time remind everyone that the open lab notebooks that can be found on malaria.ourexperiment.org are our lab notebooks and not to be taken as publication ready procedures. They record our findings as we get them so we will update the entries with further information when we receive it.