Synthesis Strategy for Near Neighbours

The evaluation of a synthesis strategy toward "near neighbours" of the TCMDC-123812 and -123794 is underway. Current efforts summarised as shown below:
Near Neighbour Synthesis
The experimental details are outlined in experiments PMY 13-1, PMY 14-1 and PMY 16-1. The synthesis appears straightforward but the final hydrolysis step resulted in material that was contaminated by grease (presumably from lab glassware). I'll update when I've repeated the reaction, while avoiding introduction of grease!