Alternatives to PZQ

A hub for alternative drugs to the currently used PZQ

Naturally-occurring alternatives to PZQ

To assemble a list below of naturally-occurring alternatives to PZQ for the treatment of schistosomiasis.

Synthetic alternatives to PZQ

Synthetic compounds that are alternatives to PZQ - anyone can assemble a list below.

PZQ Analogs

Page dedicated to possible PZQ analogs. Either add below, or create child pages.

Aromatic replacements for cyclohexane moiety

The analog containing benzoyl in place of cyclohexanoyl was described in one of the early PZQ patents. Interestingly the patent says this (column 2, top): "[The enantiopure compound] exhibits its althelmintic activity on [organism] in a dose which is up to five times smaller than that of the racemic [compound]. This effect could not be expected, since one would anticipate a doubling of the efficiency at most, if only one isomer were active."