blogs

24 Sep

New bioinformatics student is ready to get involve

Published by ozsolomon

Hi all, 
I'm new here and stil unfamiliar with communicating via this site.
Ready to get involve and help with the resreach here.
I've analyzed gene expression data during my master studies,
wrote some scripts in perl and analyzed human sequence data.
Yours,
Oz

21 Sep

Now we're getting somewhere but not with the oxidation

Published by pylioja

Subject 

Miscellaneous

Ok now I'm getting close to TCMDC-123812/123794. A slight change of tack for the alternative core synthesis seems to have paid off. First alkylation of ethyl acetoacetate with chloroacetone and then condensation with 4-fluoroaniline appears to have given the pyrrole with an ester on the 3-position quite nicely in 61% yield over the two steps after recrystallisation (PMY 8-1). Sometimes it just pays to change the plan completely when you feel like progress is slow.

21 Sep

First Full Paper on a TSL Project

Published by MatTodd

Subject 

Miscellaneous

The first paper arising from the open science coordinated by this site has just been published here. Though the project is very much ongoing, it's super exciting to be able to publish a paper as a milestone. i.e. one can run an open project, and once a certain point has been reached, one can submit a paper for traditional peer review to act as a reviewed summary of progress.
 

19 Sep

Update on TCMDC-123812 and TCMDC-123794: Oxidation issues

Published by pylioja

Subject 

Rants

In the last couple of weeks my time has mostly been spent trying to figure out whats going on in the oxidation of pyrrole-3-carbaldehyde to the corresponding acid.
Reaction Scheme PY3_5.png

17 Sep

Patents, Universities and Open Source

Published by MatTodd

Community 

general open research

Subject 

Miscellaneous

Saw this very interesting article/development. Intel sponsoring research at top universities, but heavily encouraging the projects to be open source and the universities not to take out patents. A bold step, very counter to the philosophy that is so familiar to any current academic. From the website:
 

09 Mar

Doemling's Chiral Praziquantel Synthesis????

Published by CreativeChemistry

 While Doemling has published (and patented) a Ugi approach to racemic PZQ, there was also a claim in an abstract from a ASTMH meeting from December 2008 that he was to talk about a chiral synthesis (abstract below). Anyone know anything about this?
 

25 Jan

Praziquantel Update January 25 2011

Published by MatTodd

The resolution of PZQ via PZQamine is working very nicely on a gram scale. We're still tweaking and improving it. For example the initial resolving agent identified by Syncom, dianisoyl tartaric acid, can be replaced by dibenzoyl tartaric acid. The latter is easier to purify, is less expensive (to buy and probably to make) and gives the opposite (desired!) enantiomer of PZQamine in the solid. The resolving agent can also be easily recycled in good yield.

Pages