blogs

27 Nov

Project Update

Published by Alice Williamson
Where is the project up to?

We've been busy working on the synthesis of the ten 'final' aryl pyrrole compounds chosen after the consultation in July. 

This post is a brief summary of the current project status to let people know what has been achieved and which compounds still need to be conquered.

 

So here we go:

23 Nov

Getting the SAR data out there

Published by cdsouthan

Having picked up this theme from a G+ post I have written a blog entry on aspects of getting the latest SAR data into public databases (and looking after it after its out)
http://cdsouthan.blogspot.se/2012/11/getting-your-sar-data-out-there.html
 

17 Oct

Patent structures as reference compounds

Published by cdsouthan

Subject 

Request for Help

The recent small molecule anti-malarial patents review by the MMV teams is a very useful  job (http://www.citeulike.org/user/cdsouthan/article/11477246) and  the effort raises some questions.
 

08 Oct

Williamson's attempted ether synthesis

Published by Alice Williamson

Subject 

Request for Help

Hello, I’m Alice and I joined Mat Todd’s group as a Postdoc just over a month ago. I have started working on the Malaria open source drug discovery project and this is the first of many posts to come, thanks for reading and please let me know your thoughts. My first task was to synthesise compound Sd a fairly unintimidating target, especially as Paul Ylioja has developed a robust synthesis of the required alcohol 1.

02 Oct

First research update: Introductions, arrylpyrroles and sulfonates.

Published by Matin

Hello all,
I just wanted to introduce myself, I'm Matin and I started at the Todd lab in Sydney at the end of July and after 2 months I'm doing my first update on Synaptic Leap, I'll be talking about experiments which have been recorded in my lab book which can be found here.
 

24 Aug

Deciding Which Commercially Available Analogues to Buy Within the Thienopyrimidine Series

Published by JimCronshaw

Subject 

Request for Help

Analogues of the amino thienopyrimidine lead compound are needed to assess structure-activity relationship's (SAR's) of the compound. To acheive this, both novel synthetic compounds and commercially available compounds must be obtained and submitted for biological screening. The novel synthetic compounds are being synthesised in the Todd lab at the University of Sydney. The commercially available compounds were identified by performing a similarity search on eMolecules using a similarity (Tanimoto) co-efficient of 0.55.

31 Jul

Pharmacokinetics

Published by pylioja

Subject 

Results

Previously, we found that we had no efficacy for the compounds tested in our  in vivo plasmodium berghei study. Until now we haven't had our pharmacokinetic to figure out why this was. We had previously found that OSM-S-5 (PMY 10-6/TCMDC-123812) is rapidly metabolised in mouse plasma, but that it is stable in human plasma.

24 Jul

A quick compound update

Published by pylioja

Subject 

Results

Tomorrow we will be having an open chat with anyone who wants to pitch in about which compounds we should be making for the next round of testing. We've been talking about this for a while (phase 1, phase 2) and this the final call before we split some of the compounds into seperate jobs that teams can take on. In the mean time, I've made a few of the compounds we mentioned and I'm most of the way to a couple of others.

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