Jim Cronshaw from the Todd Laboratory at the University of Sydney here again for my two monthly update.

Analogues of the amino thienopyrimidine lead compound are needed to assess structure-activity relationship's (SAR's) of the compound. To acheive this, both novel synthetic compounds and commercially available compounds must be obtained and submitted for biological screening. The novel synthetic compounds are being synthesised in the Todd lab at the University of Sydney. The commercially available compounds were identified by performing a similarity search on eMolecules using a similarity (Tanimoto) co-efficient of 0.55.

Jim Cronshaw from the Todd group at the University of Sydney here again. It’s been quite some time since I made an update on my research on The Synaptic Leap. This post is intended to give an overview of what problems have been hounding me over the intervening two months.

Jim Cronshaw here. Research on my side of the Todd Lab into the synthesis of two new anti-malarial drug candidates is progressing well. As a new honours student in the Todd group, unfamiliar with the ways of a research lab, I found myself inundated with the volume of new information coming my way, though I’ve settled in nicely now. This post is intended to summarise the work I’ve completed so far.

The following compounds have been identified as potential antimalarial drugs by GSK-Tres Cantos.

The top compound, known hereafter as 'compound 3', can be found on ChEMBL and ChemSpider:
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL535225 - ChEMBL

The following compounds have been identified as potential antimalarial drugs by GSK-Tres Cantos.

The top compound, known hereafter as 'compound 3', can be found on ChEMBL and ChemSpider:
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL535225 - ChEMBL