JimCronshaw's blog

10 Dec

Advice Needed: Generation of Analogues in the Thienopyrimidine Series

Published by JimCronshaw

Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)

 

24 Aug

Deciding Which Commercially Available Analogues to Buy Within the Thienopyrimidine Series

Published by JimCronshaw

Subject 

Request for Help

Analogues of the amino thienopyrimidine lead compound are needed to assess structure-activity relationship's (SAR's) of the compound. To acheive this, both novel synthetic compounds and commercially available compounds must be obtained and submitted for biological screening. The novel synthetic compounds are being synthesised in the Todd lab at the University of Sydney. The commercially available compounds were identified by performing a similarity search on eMolecules using a similarity (Tanimoto) co-efficient of 0.55.

21 Jun

June 2012 update on two potential drug candidates from the Todd group

Published by JimCronshaw

Jim Cronshaw from the Todd group at the University of Sydney here again. It’s been quite some time since I made an update on my research on The Synaptic Leap. This post is intended to give an overview of what problems have been hounding me over the intervening two months.

11 Apr

Research updates on two potential anti-malarial drug candidates

Published by JimCronshaw

Jim Cronshaw here. Research on my side of the Todd Lab into the synthesis of two new anti-malarial drug candidates is progressing well. As a new honours student in the Todd group, unfamiliar with the ways of a research lab, I found myself inundated with the volume of new information coming my way, though I’ve settled in nicely now. This post is intended to summarise the work I’ve completed so far.

06 Feb

Proposed Synthesis of 'compound 3' and 'compound 4'

Published by JimCronshaw

The following compounds have been identified as potential antimalarial drugs by GSK-Tres Cantos.
Target Molecules
The top compound, known hereafter as 'compound 3', can be found on ChEMBL and ChemSpider:
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL535225 - ChEMBL

06 Feb

Proposed Synthesis of 'compound 3' and 'compound 4'

Published by JimCronshaw

The following compounds have been identified as potential antimalarial drugs by GSK-Tres Cantos.
Target Molecules
The top compound, known hereafter as 'compound 3', can be found on ChEMBL and ChemSpider:
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL535225 - ChEMBL