25 Jun

Open Access Future Med Chem Issue

Published by MatTodd



While this schisto community is not terribly active right now there was just published an excellent open access issue of Future Med Chem, edited by Conor Caffrey, and with articles by many of the major players in the field.

26 Feb


Published by Matin

As I alluded to at the end of my previous entry, I've been working on a way to make sulfonamides of the arryl pyrrole series for the OSDD Malaria project.

Figure 1. Examples of sulfonamides that are currently being made for testing as anti-malarials.

02 Jan

Abridged Transcript of OSDD Open Meeting (17.12.12)

Published by Alice Williamson



+OSDD Malaria, @OSDDMalaria


Matthew Houghton Todd (MHT), University of Sydney, +Matthew Todd, @MatToddChem

Paul Willis (PW), Medicines for Malaria Venture,

Murray N Robertson (MNR), University of Sydney, +Murray Robertson, @murrayfold

Alice E Williamson (AEW), University of Sydney, +Alice Williamson, @all_isee

12 Dec

Draft Agenda for OSDD Consultation:

Published by Alice Williamson

The next meeting will take place online at this location: Meeting Room 
At these times Monday 17th December 2012:
San Francisco 6 am 
New York 9 am 
London 2 pm 
Geneva 3 pm 
Delhi 7:30 pm 
Sydney 1 am (so on Tuesday 18th) 
Agenda Items: (being edited) 
1. Summary of current aryl pyrrole status and biological results

12 Dec

Pharmacophore Modelling Using The Aryl Pyrrole Data To Date.

Published by m.robertson


Request for Help

I’ve recently been doing some pharmacophore modelling of some of the OSM and GSK compounds.  I was kindly given access to the Schrodinger Suit Software by Dai Hibbs in the Faculty of Pharmacy here at Sydney.  Unfortunately, my previous experience with the Schrodinger software is rather limited and I’ve never used the Phase application before.  Anyway, I set about getting used to the software again watching all the online tutorials and reading the manuals.  After getting used to the software a nice trend in the data was found and I set about tuning this model.  Unfortunately this is where I’

10 Dec

Advice Needed: Generation of Analogues in the Thienopyrimidine Series

Published by JimCronshaw

Seasons greetings all. This is the December 2012 update from my side of the Todd lab. I have finished my honours project and submitted my thesis to obtain Hons I - which is highly pleasing - and I'm back for a period of time to assist the Todd group and their antimalarial project. Specifically, I hope to generate a variety of analogues of the hit compound within the aminothienopyrimidine series (Figure 1)


05 Dec

Summary of the ArylPyrrole Data

Published by Alice Williamson

Here is a summary of the biological data obtained for the aryl pyrroles to date:

The team have been looking for patterns in the data ahead of the next consultation. The scheme below concisely displays the patterns that have been identified at this stage of the project. More detailed analysis including the structures and activities of all compounds that have been biologically evaluated can be found on the OSDD Malaria G+ page

30 Nov

First Set of Biological Results from the Third Round of Compounds

Published by Alice Williamson


The team set about synthesising targets SA - SJ and ordered the commercial compounds chosen at the consultation in July. In late September, the commercial compounds, plus some of the synthetic targets (and analogues) were sent away for biological evaluation.