The Synaptic Leap

 Open-source science takes on neglected diseaseDeclan ButlerNature News, (04 Feb 2010)info:doi/10.1038/news.2010.50Chemist launches collaborative project to make more potent form of much-needed drug ... A chemist — and social entrepreneur — in Australia is launching an open-source research project to develop a more potent form of a front-line drug against the debilitating neglected tropical disease schistosomiasis. Matthew Todd of the University of Sydney hopes to persuade research chemists across the world to share laboratory time and expertise in a collaborative effort to find a cheap and efficient synthesis of the drug praziquantel. All results will be published in almost real time on the project's website — free of intellectual property restrictions — and later in journals, with substantial contributors becoming authors on any resulting papers. Todd, who is currently on a six-month sabbatical at Stanford University in California, had been playing with the idea since 2006. He hired a post-doc last month after receiving three-year funding of Aus$400,000 for the project — mostly from the Australian government with Aus$75,000 coming from the World Health Organization — to start putting it into practice.Posted by NatureRevMicrobiol and 1 other to schistosomiasis Schitosoma treatment research chemistry on Sat Feb 06 2010 at 03:41 UTC | info | related

 Sequencing unlocks secrets of blood parasites - on articles in NatureSequencing unlocks secrets of blood parasitesKerri SmithNature News, (15 Jul 2009)info:doi/10.1038/news.2009.692Possible drug targets revealed in flatworms that cause schistosomiasis ... Researchers have sequenced the genomes of two species of flatworm that cause the tropical disease schistosomiasis, revealing potential weaknesses that could be exploited by drug developers. Schistosomiasis — also called bilharzia — is transmitted by water-borne snails, and affects more than 200 million people, many of whom live in Africa. Infections are usually chronic, rather than fatal. There is currently only one drug, praziquantel, in use against schistosomiasis and, although it is effective, scientists don't understand exactly how it works. An international team led by Matthew Berriman at the Wellcome Trust Sanger Institute in Cambridge, UK, and Najib El-Sayed at the University of Maryland in College Park has sequenced the genome of the parasite found throughout Africa (Schistosoma mansoni). The Asian strain (S. japonicum) was tackled by the Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium.Posted by NatureRevMicrobiol to flatworms Schistosoma japonicum schistosomiasis schistosoma Schistosoma mansoni genomes on Thu Jul 16 2009 at 03:35 UTC | info | related

 The NIH-NIAID Schistosomiasis Resource CenterPLoS Neglected Tropical Diseases 2 (7), e267 (2008)info:doi/10.1371/journal.pntd.0000267Posted by Papps to Resource Center schistosomiasis NIH on Thu Sep 11 2008 at 22:29 UTC | info | related

 Comparative evolution of the fluorescent antibodies directed against the larval stages and the adults of Schistosoma mansoni. I. Experimental schistosomiasis in untreated miceT Kien Truong, G Sarasin, and P Ambroise-ThomasAnnals of tropical medicine and parasitology 64 (1), 87-92 (Mar 1970)info:pmid/4922149Posted by gjwilliams2 to schistosomiasis Antibody Formation Larva schistosoma Fluorescent Antibody Technique growth & development female liver pancreas animals pathology mice immunology on Thu Jul 03 2008 at 00:15 UTC | info | related

 Comarative evolution of the fluorescent antibodies directed against the larval stages and the adults of Schistosoma mansoni. II. Experimental schistosomiasis in mice after treatment with niridazoleP Ambroise-Thomas, G Sarasin, and T Kien TruongAnnals of tropical medicine and parasitology 64 (1), 93-9 (Mar 1970)info:pmid/4922150Posted by gjwilliams2 to Anthelmintics Stimulation, Chemical Thiazoles schistosomiasis Antibody Formation schistosoma drug therapy therapeutic use Fluorescent Antibody Technique Imidazoles growth & development female animals mice immunology on Wed Jul 02 2008 at 23:28 UTC | info | related

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