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Within-host competition can delay evolution of drug resistance in malaria

CiteULike malaria tags - 11 September 2018 - 6:40pm
PLOS Biology, Vol. 16, No. 8. (21 August 2018), e2005712, doi:10.1371/journal.pbio.2005712
Mary Bushman, Rustom Antia, Venkatachalam Udhayakumar, Jacobus de Roode
Categories: malaria news feeds

List of keywords of the INRMM meta-information database - part 23

CiteULike malaria tags - 7 September 2018 - 5:11pm
(February 2014)

List of indexed keywords within the transdisciplinary set of domains which relate to the Integrated Natural Resources Modelling and Management (INRMM). In particular, the list of keywords maps the semantic tags in the INRMM Meta-information Database (INRMM-MiD). [\n] The INRMM-MiD records providing this list are accessible by the special tag: inrmm-list-of-tags ( http://mfkp.org/INRMM/tag/inrmm-list-of-tags ).
Categories: malaria news feeds

Inducible developmental reprogramming redefines commitment to sexual development in the malaria parasite Plasmodium berghei

CiteULike malaria tags - 6 September 2018 - 10:35am
Nature Microbiology (3 September 2018), doi:10.1038/s41564-018-0223-6
Robyn Kent, Katarzyna Modrzynska, Rachael Cameron, Nisha Philip, Oliver Billker, Andrew Waters
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Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution

CiteULike malaria tags - 30 August 2018 - 10:34am
PLOS Biology, Vol. 16, No. 8. (24 August 2018), e2006035, doi:10.1371/journal.pbio.2006035
Aude Gilabert, Thomas Otto, Gavin Rutledge, Blaise Franzon, Benjamin Ollomo, Céline Arnathau, Patrick Durand, Nancy Moukodoum, Alain-Prince Okouga, Barthélémy Ngoubangoye, Boris Makanga, Larson Boundenga, Christophe Paupy, François Renaud, Franck Prugnolle, Virginie Rougeron
Categories: malaria news feeds

Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia

CiteULike malaria tags - 24 August 2018 - 8:13am
Scientific Reports, Vol. 8, No. 1. (22 August 2018), doi:10.1038/s41598-018-30593-5
Duangkamon Bunditvorapoom, Theerarat Kochakarn, Namfon Kotanan, Charin Modchang, Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Thanyaluk Krasae, Liwang Cui, Kesinee Chotivanich, Nicholas White, Prapon Wilairat, Olivo Miotto, Thanat Chookajorn
Categories: malaria news feeds

Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites

CiteULike malaria tags - 23 August 2018 - 10:09am
Proceedings of the National Academy of Sciences (20 August 2018), 201810053, doi:10.1073/pnas.1810053115
Dorothy Loy, Lindsey Plenderleith, Sesh Sundararaman, Weimin Liu, Jakub Gruszczyk, Yi-Jun Chen, Stephanie Trimboli, Gerald Learn, Oscar MacLean, Alex Morgan, Yingying Li, Alexa Avitto, Jasmin Giles, Sébastien Calvignac-Spencer, Andreas Sachse, Fabian Leendertz, Sheri Speede, Ahidjo Ayouba, Martine Peeters, Julian Rayner, Wai-Hong Tham, Paul Sharp, Beatrice Hahn
Categories: malaria news feeds

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

CiteULike malaria tags - 20 August 2018 - 8:10am
Nature Communications, Vol. 9, No. 1. (17 August 2018), doi:10.1038/s41467-018-05652-0
Leila Ross, Satish Dhingra, Sachel Mok, Tomas Yeo, Kathryn Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick Fairhurst, Frederic Ariey, Didier Menard, David Fidock
Categories: malaria news feeds

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

CiteULike malaria tags - 26 July 2018 - 11:36am
The Lancet Haematology (July 2018), doi:10.1016/s2352-3026(18)30107-8
Carolyne Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret Mackinnon, Kathryn Maitland, Dominic Kwiatkowski, Kirk Rockett, Thomas Williams, Amadou Abathina, Ismaela Abubakar, Eric Achidi, Tsiri Agbenyega, Mohammed Aiyegbo, Alex Akoto, Angela Allen, Stephen Allen, Lucas Amenga-Etego, Folakemi Amodu, Olukemi Amodu, Judith Anchang-Kimbi, Nana Ansah, Patrick Ansah, Daniel Ansong, Sampson Antwi, Thomas Anyorigiya, Tobias Apinjoh, Emmanuel Asafo-Agyei, Victor Asoala, Frank Atuguba, Sarah Auburn, Abdou Bah, Kariatou Bamba, Germana Bancone, Gavin Band, David Barnwell, Abdoulaye Barry, Evasius Bauni, Richard Besingi, Kalifa Bojang, Edith Bougouma, Susan Bull, George Busby, Abdoulie Camara, Landing Camara, Susana Campino, Richard Carter, Dan Carucci, Climent Casals-Pascual, Ndey Ceesay, Pa Ceesay, Tran Chau, Ly Chuong, Taane Clark, Geraldine Clarke, Ramou Cole-Ceesay, David Conway, Katharine Cook, Olivia Cook, Victoria Cornelius, Patrick Corran, Simon Correa, Sharon Cox, Rachel Craik, Bakary Danso, Timothy Davis, Nicholas Day, Panos Deloukas, Awa Dembele, Jantina deVries, Rajika Dewasurendra, Mahamadou Diakite, Elizabeth Diarra, Yaya Dibba, Andrea Diss, Abdoulaye Djimdé, Amagana Dolo, Ogobara Doumbo, Alan Doyle, Chris Drakeley, Eleanor Drury, Patrick Duffy, Sarah Dunstan, Augustine Ebonyi, Ahmed Elhassan, Ibrahim Elhassan, Abier Elzein, Anthony Enimil, Pamela Esangbedo, Jennifer Evans, Julie Evans, Jeremy Farrar, Deepika Fernando, Kathryn Fitzpatrick, Janet Fullah, Jacob Garcia, Anita Ghansah, Michael Gottleib, Angie Green, Lee Hart, Meike Hennsman, Tran Hien, Nguyen Hieu, Eliza Hilton, Abraham Hodgson, Rolf Horstmann, Christina Hubbart, Catherine Hughes, Ayman Hussein, Robert Hutton, Muntaser Ibrahim, Deus Ishengoma, Jula Jaiteh, Mariatou Jallow, Muminatou Jallow, Kebba Jammeh, Momodou Jasseh, Anna Jeffreys, Amie Jobarteh, Kimberly Johnson, Sarah Joseph, Dushyanth Jyothi, David Kachala, Dorcas Kamuya, Haddy Kanyi, Harin Karunajeewa, Nadira Karunaweera, Momodou Keita, Angeliki Kerasidou, Aja Khan, Katja Kivinen, Gilbert Kokwaro, Amadou Konate, Salimata Konate, Kwadwo Koram, Dominic Kwiatkowski, Moses Laman, Si Le, Ellen Leffler, Martha Lemnge, Enmoore Lin, Alioune Ly, Alexander Macharia, Bronwyn MacInnis, Nguyen Mai, Julie Makani, Cinzia Malangone, Valentina Mangano, Alphaxard Manjurano, Lamin Manneh, Laurens Manning, Magnus Manske, Kevin Marsh, Vicki Marsh, Gareth Maslen, Caroline Maxwell, Eric Mbunwe, Marilyn McCreight, Daniel Mead, Alieu Mendy, Anthony Mendy, Nathan Mensah, Pascal Michon, Alistair Miles, Olivo Miotto, David Modiano, Hiba Mohamed, Sile Molloy, Malcolm Molyneux, Sassy Molyneux, Mike Moore, Catherine Moyes, Frank Mtei, George Mtove, Ivo Mueller, Regina Mugri, Annie Munthali, Theonest Mutabingwa, Behzad Nadjm, Andre Ndi, Carolyne Ndila, Charles Newton, Amadou Niangaly, Haddy Njie, Jalimory Njie, Madi Njie, Malick Njie, Sophie Njie, Labes Njiragoma, Francis Nkrumah, Neema Ntunthama, Aceme Nyika, Vysaul Nyirongo, John O'Brien, Herbert Obu, Abraham Oduro, Alex Ofori, Subulade Olaniyan, Rasaq Olaosebikan, Tom Oluoch, Olayemi Omotade, Olajumoke Oni, Emmanuel Onykwelu, Daniel Opi, Adebola Orimadegun, Sean O'Riordan, Issa Ouedraogo, Samuel Oyola, Michael Parker, Richard Pearson, Paul Pensulo, Norbert Peshu, Ajib Phiri, Nguyen Phu, Margaret Pinder, Matti Pirinen, Chris Plowe, Claire Potter, Belco Poudiougou, Odile Puijalon, Nguyen Quyen, Ioannis Ragoussis, Jiannis Ragoussis, Oba Rasheed, John Reeder, Hugh Reyburn, Eleanor Riley, Paul Risley, Kirk Rockett, Joanne Rodford, Jane Rogers, William Rogers, Kate Rowlands, Valentín Ruano-Rubio, Kumba Sabally-Ceesay, Abubacar Sadiq, Momodou Saidy-Khan, Horeja Saine, Anavaj Sakuntabhai, Abdourahmane Sall, David Sambian, Idrissa Sambou, Miguel SanJoaquin, Nuno Sepúlveda, Shivang Shah, Jennifer Shelton, Peter Siba, Nilupa Silva, Cameron Simmons, Jaques Simpore, Pratap Singhasivanon, Dinh Sinh, Sodiomon Sirima, Giorgio Sirugo, Fatoumatta Sisay-Joof, Sibiry Sissoko, Kerrin Small, Elilan Somaskantharajah, Chris Spencer, Jim Stalker, Marryat Stevens, Prapat Suriyaphol, Justice Sylverken, Bintou Taal, Adama Tall, Terrie Taylor, Yik Teo, Cao Thai, Mahamadou Thera, Vincent Titanji, Ousmane Toure, Marita Troye-Blomberg, Stanley Usen, Sophie Uyoga, Aaron Vanderwal, Hannah Wangai, Renee Watson, Thomas Williams, Michael Wilson, Rebecca Wrigley, Clarisse Yafi, Lawrence Yamoah
Categories: malaria news feeds

Malaria Vaccines: Recent Advances and New Horizons

CiteULike malaria tags - 19 July 2018 - 10:47am
Cell Host & Microbe, Vol. 24, No. 1. (July 2018), pp. 43-56, doi:10.1016/j.chom.2018.06.008
Simon Draper, Brandon Sack, Richter King, Carolyn Nielsen, Julian Rayner, Matthew Higgins, Carole Long, Robert Seder
Categories: malaria news feeds

A cross-sectional analysis of ITN and IRS coverage in Namibia in 2013

CiteULike malaria tags - 19 July 2018 - 10:23am
Malaria Journal, Vol. 17, No. 1. (16 July 2018), doi:10.1186/s12936-018-2417-z
Sophie Allcock, Elizabeth Young, Manjinder Sandhu
Categories: malaria news feeds

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

CiteULike malaria tags - 5 July 2018 - 11:40am
Science Translational Medicine, Vol. 10, No. 447. (27 June 2018), eaar3619, doi:10.1126/scitranslmed.aar3619
Hyun Lee, Athina Georgiadou, Michael Walther, Davis Nwakanma, Lindsay Stewart, Michael Levin, Thomas Otto, David Conway, Lachlan Coin, Aubrey Cunnington
Categories: malaria news feeds

Cryo-EM structure of an essential Plasmodium vivax invasion complex

CiteULike malaria tags - 5 July 2018 - 11:36am
Nature, Vol. 559, No. 7712. (27 June 2018), pp. 135-139, doi:10.1038/s41586-018-0249-1
Jakub Gruszczyk, Rick Huang, Li-Jin Chan, Sébastien Menant, Chuan Hong, James Murphy, Yee-Foong Mok, Michael Griffin, Richard Pearson, Wilson Wong, Alan Cowman, Zhiheng Yu, Wai-Hong Tham
Categories: malaria news feeds

RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics

CiteULike malaria tags - 5 July 2018 - 10:10am
PLOS Genetics, Vol. 14, No. 7. (2 July 2018), e1007490, doi:10.1371/journal.pgen.1007490

The malaria parasite Plasmodium falciparum has evolved an unusual genome structure. The majority of the genome is relatively stable, with mutation rates similar to most eukaryotic species. However, some regions are very unstable with high recombination rates, driving the generation of new immune evasion-associated var genes. The molecular factors controlling the inconsistent stability of this genome are not known. Here we studied the roles of the two putative RecQ helicases in P. falciparum, PfBLM and PfWRN. When PfWRN was knocked down, recombination rates increased four-fold, generating chromosomal abnormalities, a high rate of chimeric var genes and many microindels, particularly in known ‘fragile sites’. This is the first identification of a gene involved in suppressing recombination and maintaining genome stability in Plasmodium. By contrast, no change in mutation rate appeared when the second RecQ helicase, PfBLM, was mutated. At the transcriptional level, however, both helicases evidently modulate the transcription of large cohorts of genes, with several hundred genes—including a large proportion of vars—showing deregulated expression in each RecQ mutant. Aberrant processing of stalled replication forks is a possible mechanism underlying elevated mutation rates and this was assessed by measuring DNA replication dynamics in the RecQ mutant lines. Replication forks moved slowly and stalled at elevated rates in both mutants, confirming that RecQ helicases are required for efficient DNA replication. Overall, this work identifies the Plasmodium RecQ helicases as major players in DNA replication, antigenic diversification and genome stability in the most lethal human malaria parasite, with important implications for genome evolution in this pathogen. Human malaria is caused by Plasmodium parasites, with most of the mortality (almost half a million deaths each year) being caused by one species, Plasmodium falciparum. This parasite has an unusual genome: it is exceptionally biased towards A and T nucleotides rather than G and C, and it contains specific areas rich in hypervariable virulence-associated genes which evolve very rapidly to produce new variants. This evolution is probably vital for the parasite to evade the human immune system and maintain chronic infections, but how it is controlled at a molecular level remains unknown. We have identified a helicase in the parasite with a huge influence on genome stability and the rate of genome evolution. It appears to function by unwinding various unusual DNA structures, and if this fails then the genome becomes unstable. In addition, the transcription of many genes whose DNA tends to form secondary structures is affected, and DNA replication is impeded. If this helicase was expressed variably in different parasite strains infecting humans, it could influence the parasites’ ability to grow and replicate efficiently, and also, crucially, its ability to evolve and thus evade the human immune system.
Antoine Claessens, Lynne Harris, Slavica Stanojcic, Lia Chappell, Adam Stanton, Nada Kuk, Pamela Veneziano-Broccia, Yvon Sterkers, Julian Rayner, Catherine Merrick
Categories: malaria news feeds

Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics

CiteULike malaria tags - 5 July 2018 - 9:54am
Nature Communications, Vol. 9, No. 1. (3 July 2018), doi:10.1038/s41467-018-04965-4
Sarah Auburn, Ernest Benavente, Olivo Miotto, Richard Pearson, Roberto Amato, Matthew Grigg, Bridget Barber, Timothy William, Irene Handayuni, Jutta Marfurt, Hidayat Trimarsanto, Rintis Noviyanti, Kanlaya Sriprawat, Francois Nosten, Susana Campino, Taane Clark, Nicholas Anstey, Dominic Kwiatkowski, Ric Price
Categories: malaria news feeds

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia

CiteULike malaria tags - 28 June 2018 - 10:10am
Scientific Reports, Vol. 8, No. 1. (26 June 2018), doi:10.1038/s41598-018-28017-5
Alfred Amambua-Ngwa, David Jeffries, Roberto Amato, Archibald Worwui, Mane Karim, Sukai Ceesay, Haddy Nyang, Davis Nwakanma, Joseph Okebe, Dominic Kwiatkowski, David Conway, Umberto D’Alessandro
Categories: malaria news feeds

Malaria.

CiteULike malaria tags - 22 June 2018 - 4:00am
Lancet (London, England), Vol. 391, No. 10130. (21 April 2018), pp. 1608-1621

Following unsuccessful eradication attempts there was a resurgence of malaria towards the end of the 20th century. Renewed control efforts using a range of improved tools, such as long-lasting insecticide-treated bednets and artemisinin-based combination therapies, have more than halved the global burden of disease, but it remains high with 445 000 deaths and more than 200 million cases in 2016. Pitfalls in individual patient management are delayed diagnosis and overzealous fluid resuscitation in severe malaria. Even in the absence of drug resistance, parasite recurrence can occur, owing to high parasite densities, low host immunity, or suboptimal drug concentrations. Malaria elimination is firmly back as a mainstream policy but resistance to the artemisinin derivatives, their partner drugs, and insecticides present major challenges. Vaccine development continues on several fronts but none of the candidates developed to date have been shown to provide long-lasting benefits at a population level. Increased resources and unprecedented levels of regional cooperation and societal commitment will be needed if further substantial inroads into the malaria burden are to be made. Copyright © 2018 Elsevier Ltd. All rights reserved.
Elizabeth Ashley, Aung Pyae Phyo, Charles Woodrow
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A Surveillance Infrastructure for Malaria Analytics: Provisioning Data Access and Preservation of Interoperability

CiteULike malaria tags - 16 June 2018 - 8:18am
JMIR Public Health Surveill, Vol. 4, No. 2. (15 Jun 2018), doi:10.2196/10218

Background: According to the World Health Organization, malaria surveillance is weakest in countries and regions with the highest malaria burden. A core obstacle is that the data required to perform malaria surveillance are fragmented in multiple data silos distributed across geographic regions. Furthermore, consistent integrated malaria data sources are few, and a low degree of interoperability exists between them. As a result, it is difficult to identify disease trends and to plan for effective interventions. Objective: We propose the Semantics, Interoperability, and Evolution for Malaria Analytics (SIEMA) platform for use in malaria surveillance based on semantic data federation. Using this approach, it is possible to access distributed data, extend and preserve interoperability between multiple dynamic distributed malaria sources, and facilitate detection of system changes that can interrupt mission-critical global surveillance activities. Methods: We used Semantic Automated Discovery and Integration (SADI) Semantic Web Services to enable data access and improve interoperability, and the graphical user interface-enabled semantic query engine HYDRA to implement the target queries typical of malaria programs. We implemented a custom algorithm to detect changes to community-developed terminologies, data sources, and services that are core to SIEMA. This algorithm reports to a dashboard. Valet SADI is used to mitigate the impact of changes by rebuilding affected services. Results: We developed a prototype surveillance and change management platform from a combination of third-party tools, community-developed terminologies, and custom algorithms. We illustrated a methodology and core infrastructure to facilitate interoperable access to distributed data sources using SADI Semantic Web services. This degree of access makes it possible to implement complex queries needed by our user community with minimal technical skill. We implemented a dashboard that reports on terminology changes that can render the services inactive, jeopardizing system interoperability. Using this information, end users can control and reactively rebuild services to preserve interoperability and minimize service downtime. Conclusions: We introduce a framework suitable for use in malaria surveillance that supports the creation of flexible surveillance queries across distributed data resources. The platform provides interoperable access to target data sources, is domain agnostic, and with updates to core terminological resources is readily transferable to other surveillance activities. A dashboard enables users to review changes to the infrastructure and invoke system updates. The platform significantly extends the range of functionalities offered by malaria information systems, beyond the state-of-the-art.
Sadnan Al Manir, Haël Brenas, Jo Baker, Arash Shaban-Nejad
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The genomics of insecticide resistance: insights from recent studies in African malaria vectors

CiteULike malaria tags - 14 June 2018 - 9:45am
Current Opinion in Insect Science (June 2018), doi:10.1016/j.cois.2018.05.017
Chris Clarkson, Helen Temple, Alistair Miles
Categories: malaria news feeds

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria

CiteULike malaria tags - 14 June 2018 - 9:19am
PLOS ONE, Vol. 13, No. 6. (8 June 2018), e0198371, doi:10.1371/journal.pone.0198371

Plasmodium falciparum PfRH5 protein binds Ripr, CyRPA and Pf113 to form a complex that is essential for merozoite invasion of erythrocytes. The inter-genomic conservation of the PfRH5 complex proteins makes them attractive blood stage vaccine candidates. However, little is known about how antibodies to PfRH5, CyRPA and Pf113 are acquired and maintained in naturally exposed populations, and the role of PfRH5 complex proteins in naturally acquired immunity. To provide such data, we studied 206 Ghanaian children between the ages of 1–12 years, who were symptomatic, asymptomatic or aparasitemic and healthy. Plasma levels of antigen-specific IgG and IgG subclasses were measured by ELISA at several time points during acute disease and convalescence. On the day of admission with acute P. falciparum malaria, the prevalence of antibodies to PfRH5-complex proteins was low compared to other merozoite antigens (EBA175, GLURP-R0 and GLURP-R2). At convalescence, the levels of RH5-complex-specific IgG were reduced, with the decay of PfRH5-specific IgG being slower than the decay of IgG specific for CyRPA and Pf113. No correlation between IgG levels and protection against P. falciparum malaria was observed for any of the PfRH5 complex proteins. From this we conclude that specific IgG was induced against proteins from the PfRH5-complex during acute P. falciparum malaria, but the prevalence was low and the IgG levels decayed rapidly after treatment. These data indicate that the levels of IgG specific for PfRH5-complex proteins in natural infections in Ghanaian children were markers of recent exposure only.
Frederica Partey, Filip Castberg, Edem Sarbah, Sarah Silk, Gordon Awandare, Simon Draper, Nicholas Opoku, Margaret Kweku, Michael Ofori, Lars Hviid, Lea Barfod
Categories: malaria news feeds